Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity

Gollackner, Bernd; Goh, Seo Kiat; Qawi, Imrana; Buehler, Leo Hans; Knosalla, Christoph; Daniel, Soizic; Kaczmarek, Elzbieta; Awwad, Michel; Cooper, David K C; Robson, Simon C

doi:10.1097/01.tp.0000131167.21930.b8

Scientific article

English

Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity

ContributorsGollackner, Bernd; Goh, Seo Kiat; Qawi, Imrana; Buehler, Leo Hans; Knosalla, Christoph; Daniel, Soizic; Kaczmarek, Elzbieta; Awwad, Michel; Cooper, David K C; Robson, Simon C

Published inTransplantation, vol. 77, no. 11, p. 1735-1741

Publication date2004

Abstract

Hyperacute rejection of vascularized discordant xenografts can now be effectively managed. However, acute vascular rejection (AVR) then ensues, resulting in graft destruction, coagulopathy, or both within weeks. The aim of this study was to determine associations between humoral responses to the xenograft and the induction of AVR, coagulopathy, or both.

Keywords

Acute Disease
Animals
Antibodies, Heterophile/immunology
Aorta
Blood
Blood Coagulation Disorders/immunology
Cells, Cultured
Endothelium, Vascular/drug effects/immunology/metabolism
Graft Rejection/pathology
Immunization
Kidney Transplantation
Papio
Plant Lectins/pharmacology
Swine
Thromboplastin/metabolism
Transplantation, Heterologous

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Citation (ISO format)

GOLLACKNER, Bernd et al. Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity. In: Transplantation, 2004, vol. 77, n° 11, p. 1735–1741. doi: 10.1097/01.tp.0000131167.21930.b8

Article (Published version)

Identifiers

PID : unige:41704
DOI : 10.1097/01.tp.0000131167.21930.b8
PMID : 15201675

Journal ISSN0041-1337

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Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity

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