Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity

Gollackner, Bernd; Goh, Seo Kiat; Qawi, Imrana; Buehler, Leo Hans; Knosalla, Christoph; Daniel, Soizic; Kaczmarek, Elzbieta; Awwad, Michel; Cooper, David K C; Robson, Simon C

doi:10.1097/01.tp.0000131167.21930.b8

Article scientifique

Anglais

Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity

Contributeurs/tricesGollackner, Bernd; Goh, Seo Kiat; Qawi, Imrana; Buehler, Leo Hans; Knosalla, Christoph; Daniel, Soizic; Kaczmarek, Elzbieta; Awwad, Michel; Cooper, David K C; Robson, Simon C

Publié dansTransplantation, vol. 77, no. 11, p. 1735-1741

Date de publication2004

Résumé

Hyperacute rejection of vascularized discordant xenografts can now be effectively managed. However, acute vascular rejection (AVR) then ensues, resulting in graft destruction, coagulopathy, or both within weeks. The aim of this study was to determine associations between humoral responses to the xenograft and the induction of AVR, coagulopathy, or both.

Mots-clés

Acute Disease
Animals
Antibodies, Heterophile/immunology
Aorta
Blood
Blood Coagulation Disorders/immunology
Cells, Cultured
Endothelium, Vascular/drug effects/immunology/metabolism
Graft Rejection/pathology
Immunization
Kidney Transplantation
Papio
Plant Lectins/pharmacology
Swine
Thromboplastin/metabolism
Transplantation, Heterologous

Structure d'affiliation

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Groupe de recherche

Citation (format ISO)

GOLLACKNER, Bernd et al. Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity. In: Transplantation, 2004, vol. 77, n° 11, p. 1735–1741. doi: 10.1097/01.tp.0000131167.21930.b8

Article (Published version)

Identifiants

PID : unige:41704
DOI : 10.1097/01.tp.0000131167.21930.b8
PMID : 15201675

ISSN du journal0041-1337

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Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity

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