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Scientific article
English

Transition metal-free asymmetric and diastereoselective allylic alkylation using Grignard reagents: construction of vicinal stereogenic centers via kinetic resolution

Published inChemical science, vol. 5, no. 10, p. 3803-3807
Publication date2014
Abstract

The first transition metal-free diastereoselective and enantioselective asymmetric allylic alkylation (AAA) has been disclosed leading to the construction of vicinal tertiary/quaternary centers via a kinetic resolution protocol starting from readily available starting materials. This procedure is chemically appealing since no consecutive AAA or stereoselective metal-catalyzed/chiral ligand AAAs are required to construct the two stereocenters.

Citation (ISO format)
GRASSI, David, ALEXAKIS, Alexandre. Transition metal-free asymmetric and diastereoselective allylic alkylation using Grignard reagents: construction of vicinal stereogenic centers via kinetic resolution. In: Chemical science, 2014, vol. 5, n° 10, p. 3803–3807. doi: 10.1039/C4SC01003E
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ISSN of the journal2041-6520
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Creation11/03/2014 3:33:00 PM
First validation11/03/2014 3:33:00 PM
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