The Scientific objectives of the LOFT mission, e.g., the study of the Neutron Star equation of state and of the Strong Gravity, require accurate energy, time and flux calibration for the 516k channels of the SDD detectors, as well as the knowledge of the detector dead time and of the detector response with respect to the incident angle of the photons. We report here the evaluations made to assess the calibration issues for the LAD instrument. The strategies for both ground and on-board calibrations, including astrophysical observations, show that the goals are achievable within the current technologies. © (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.