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Human islet allotransplantation: world experience and current status

Published in Digestive surgery. 1998, vol. 15, no. 6, p. 656-62
Abstract Currently type-I diabetes mellitus is treated with exogenous insulin administration, but traditional insulin therapy does not prevent long-term systemic complications and therefore alternatives should be sought. Presently the only option is to substitute the insulin-producing beta cells in order to obtain a more physiological way to deliver insulin. Simultaneous kidney and pancreas transplantation is an established procedure. Pancreas transplantation, however, is a major surgical procedure with a high rate of complications. Transplantation of the isolated insulin-secreting islets of Langerhans is an alternative approach, which is easier and safer than whole organ transplantation. Since 1990, clinical trials of islet transplantation have begun in a few specialized centers worldwide and the International Islet Registry counting 305 human islet allografts at the end of 1995. Insulin independence at 1 year was achieved in 8% of the patients, but 20% of cases showed a graft function with a normal basal C peptide and improved glycemic regulation. We review here the different aspects of human islets of Langerhans allotransplatation, namely historical aspects, indications, isolation and purification procedures and the results obtained.
Keywords Cryopreservation/methodsCulture Techniques/methodsDiabetes Mellitus, Type 1/etiology/surgeryForecastingGraft SurvivalHumansIslets of Langerhans Transplantation/methodsPancreas/surgeryPrognosisTissue DonorsTransplantation, HomologousWorld Health Organization
PMID: 9845631
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Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
Hépatologie chirurgicale (327)
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CRETIN, Nathalie et al. Human islet allotransplantation: world experience and current status. In: Digestive surgery, 1998, vol. 15, n° 6, p. 656-62. https://archive-ouverte.unige.ch/unige:41295

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Deposited on : 2014-10-29

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