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Scientific Article - Review
unige:41295 
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Human islet allotransplantation: world experience and current status |
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| Authors | ||
| Published in | Digestive surgery. 1998, vol. 15, no. 6, p. 656-62 | |
| Abstract | Currently type-I diabetes mellitus is treated with exogenous insulin administration, but traditional insulin therapy does not prevent long-term systemic complications and therefore alternatives should be sought. Presently the only option is to substitute the insulin-producing beta cells in order to obtain a more physiological way to deliver insulin. Simultaneous kidney and pancreas transplantation is an established procedure. Pancreas transplantation, however, is a major surgical procedure with a high rate of complications. Transplantation of the isolated insulin-secreting islets of Langerhans is an alternative approach, which is easier and safer than whole organ transplantation. Since 1990, clinical trials of islet transplantation have begun in a few specialized centers worldwide and the International Islet Registry counting 305 human islet allografts at the end of 1995. Insulin independence at 1 year was achieved in 8% of the patients, but 20% of cases showed a graft function with a normal basal C peptide and improved glycemic regulation. We review here the different aspects of human islets of Langerhans allotransplatation, namely historical aspects, indications, isolation and purification procedures and the results obtained. | |
| Keywords | Cryopreservation/methods — Culture Techniques/methods — Diabetes Mellitus, Type 1/etiology/surgery — Forecasting — Graft Survival — Humans — Islets of Langerhans Transplantation/methods — Pancreas/surgery — Prognosis — Tissue Donors — Transplantation, Homologous — World Health Organization | |
| Identifiers | PMID: 9845631 | |
| Full text |
Article (Published version) (276 Kb) - Limited access to UNIGE Other version: http://www.karger.com/Article/FullText/18672 |
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| Structures | ||
| Research groups | Chirurgie viscérale (104) Chirurgie viscérale (HUG) Hépatologie chirurgicale (327) | |
| Citation (ISO format) | CRETIN, Nathalie et al. Human islet allotransplantation: world experience and current status. In: Digestive surgery, 1998, vol. 15, n° 6, p. 656-62. https://archive-ouverte.unige.ch/unige:41295 |
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