Scientific article
Case report

Primary hepatic diffuse large B-cell lymphoma in a patient with chronic hepatitis C

Published inThe American journal of surgical pathology, vol. 23, no. 9, p. 1124-1130
Publication date1999

Epidemiological and experimental data suggest that the hepatitis C virus infection might be associated with the development of distinct types of non-Hodgkin's lymphomas. Here, we report a case of a patient with chronic hepatitis C and type II mixed cryoglobulinemia, who developed a primary hepatic non-Hodgkin's B-cell lymphoma. A diffuse, large B-cell lymphoma was diagnosed based on morphological, immunophenotypical and molecular genetic findings. Hepatitis C virus replication, as evaluated by strand-specific reverse transcriptase-polymerase chain reaction, was detected in the nonneoplastic liver, but not in the lymphomatous tissue. High grade non-Hodgkin's lymphomas, although rare complications, have to be considered as part of the spectrum of hepatitis C virus-related hepatic lesions.

  • Cryoglobulinemia/etiology
  • Hepacivirus/isolation & purification
  • Hepatitis C, Chronic/complications
  • Humans
  • Liver Neoplasms/etiology/pathology/physiopathology/radiography
  • Lymphoma, B-Cell/etiology/pathology/physiopathology/radiography
  • Male
  • Middle Aged
Citation (ISO format)
RUBBIA-BRANDT, Laura et al. Primary hepatic diffuse large B-cell lymphoma in a patient with chronic hepatitis C. In: The American journal of surgical pathology, 1999, vol. 23, n° 9, p. 1124–1130.
Main files (1)
Article (Published version)
ISSN of the journal0147-5185

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