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Title

Primary hepatic diffuse large B-cell lymphoma in a patient with chronic hepatitis C.

Authors
Kerl, K
Nador, R
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Published in American Journal of Surgical Pathology. 1999, vol. 23, no. 9, p. 1124-30
Abstract Epidemiological and experimental data suggest that the hepatitis C virus infection might be associated with the development of distinct types of non-Hodgkin's lymphomas. Here, we report a case of a patient with chronic hepatitis C and type II mixed cryoglobulinemia, who developed a primary hepatic non-Hodgkin's B-cell lymphoma. A diffuse, large B-cell lymphoma was diagnosed based on morphological, immunophenotypical and molecular genetic findings. Hepatitis C virus replication, as evaluated by strand-specific reverse transcriptase-polymerase chain reaction, was detected in the nonneoplastic liver, but not in the lymphomatous tissue. High grade non-Hodgkin's lymphomas, although rare complications, have to be considered as part of the spectrum of hepatitis C virus-related hepatic lesions.
Keywords Cryoglobulinemia/etiologyHepacivirus/isolation & purificationHepatitis C, Chronic/complicationsHumansLiver Neoplasms/etiology/pathology/physiopathology/radiographyLymphoma, B-Cell/etiology/pathology/physiopathology/radiographyMaleMiddle Aged
Identifiers
PMID: 10478674
Full text
Article (Published version) (4.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Métastases du foie (657)
Hépatologie chirurgicale (327)
Etudes et traitement de l'hépatite C et B (554)
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RUBBIA-BRANDT, Laura et al. Primary hepatic diffuse large B-cell lymphoma in a patient with chronic hepatitis C. In: American Journal of Surgical Pathology, 1999, vol. 23, n° 9, p. 1124-30. https://archive-ouverte.unige.ch/unige:41199

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Deposited on : 2014-10-27

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