UNIGE document Scientific Article
previous document  unige:4112  next document
add to browser collection

Positive association of DRB1 04 and DRB1 15 alleles with Fya immunization in a Southern European population

Picard, Christophe
Frassati, Coralie
Basire, Agnes
Galicher, Vital
Ferrera, Virginie
Reviron, Denis
Zappitelli, Jean-Pierre
show hidden authors show all authors [1 - 10]
Published in Transfusion. 2009, vol. 49, no. 11, p. 2412-7
Abstract BACKGROUND: Anti-Fy(a) has been implicated in hemolytic transfusion reactions. However, not all Fy(a-) patients develop anti-Fy(a) after transfusion with 1 unit of blood [Fy(a+)]. This study was designed to identify HLA-DRB1 alleles associated with a predisposition to Fy(a) immunization after blood transfusion. STUDY DESIGN AND METHODS: To identify HLA-DRB1 alleles prone to immunization after blood transfusion or pregnancy, HLA-DRB1 genotyping using polymerase chain reaction with sequence-specific oligonucleotide nonradioactive probe/sequence-specific priming methods was performed on blood samples from 67 immunized patients and 200 unrelated controls from the same southern European population in a case-control retrospective study. RESULTS: Ninety-six percent of patients with anti-Fy(a) had at least one HLA-DRB1*04 or HLA-DRB1*15 allele compared to 34% of controls (p(c) < 0.001). Furthermore HLA-DRB1*04 and HLA-DRB1*1501 frequencies were significantly increased in Fy(a)-immunized patients (35% vs. 12%, p(c) < 0.001; and 30% vs. 19%, p(c) < 0.001, respectively). Among HLA-DRB1*04 allelic subtypes, DRB1*0401 and DRB1*0403 alleles were more strongly correlated with Fy(a) immunization (51% vs. 24% and 19% vs. 9%; p(c) < 0.001, respectively). CONCLUSIONS: This study indicated that HLA-DRB1*04 and DRB1*1501 are overrepresented in Fy(a)-immunized patients. The correlation between these alleles and Fy(a) immunization could be due to a particular presentation of the Fy(a) peptide in HLA-DRB1 molecules.
Keywords Human geneticsHLAImmunization
PMID: 19702653
Full text
Article (Published version) (82 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Unité d’anthropologie
(ISO format)
PICARD, Christophe et al. Positive association of DRB1 04 and DRB1 15 alleles with Fya immunization in a Southern European population. In: Transfusion, 2009, vol. 49, n° 11, p. 2412-7. https://archive-ouverte.unige.ch/unige:4112

353 hits



Deposited on : 2009-11-24

Export document
Format :
Citation style :