Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3

Rubbia-Brandt, Laura; Quadri Defilippis, Rafael; Abid, Karim; Giostra, Emiliano; Male, Pierre-Jean; Mentha, Gilles; Spahr, Laurent François Joséph; Zarski, J P; Borisch, Bettina; Hadengue, Antoine; Negro, Francesco

doi:10.1016/S0168-8278(00)80166-X

Scientific article

English

Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3

ContributorsRubbia-Brandt, Laura; Quadri Defilippis, Rafael; Abid, Karim; Giostra, Emiliano; Male, Pierre-Jean; Mentha, Gilles; Spahr, Laurent François Joséph; Zarski, J P; Borisch, Bettina; Hadengue, Antoine; Negro, Francesco

Published inJournal of hepatology, vol. 33, no. 1, p. 106-115

Publication date2000

Abstract

Patients infected with the hepatitis C virus (HCV) often have liver steatosis, suggesting the possibility of a viral cytopathic effect. The aim of this study was to correlate the occurrence and severity of liver steatosis with HCV RNA type, level and sequence of the core-encoding region.

Keywords

Adult
Aged
Amino Acid Sequence/genetics
Antiviral Agents/therapeutic use
Fatty Liver/virology
Female
Genotype
Hepacivirus/genetics
Hepatitis C, Chronic/complications/immunology/pathology/virology
Humans
Immunocompetence
Interferon-alpha/therapeutic use
Liver Cirrhosis/drug therapy/virology
Liver Transplantation
Male
Middle Aged
Molecular Sequence Data
Nucleocapsid Proteins/genetics
RNA, Viral/genetics

Affiliation entities

Research groups

Citation (ISO format)

RUBBIA-BRANDT, Laura et al. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3. In: Journal of hepatology, 2000, vol. 33, n° 1, p. 106–115. doi: 10.1016/S0168-8278(00)80166-X

Article (Published version)

Identifiers

PID : unige:41083
DOI : 10.1016/S0168-8278(00)80166-X
PMID : 10905593

Journal ISSN0168-8278

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Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3

Patients infected with the hepatitis C virus (HCV) often have liver steatosis, suggesting the possibility of a viral cytopathic effect. The aim of this study was to correlate the occurrence and severity of liver steatosis with HCV RNA type, level and sequence of the core-encoding region.

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