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Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery |
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Published in | Journal of microencapsulation. 2008, vol. 25, no. 5, p. 339-50 | |
Abstract | OBJECTIVE: Intra-articular drug delivery systems still suffer from too short-lasting effects. Magnetic particles retained in the joint using an external magnetic field might prolong the local release of an anti-inflammatory drug. For the purpose, superparamagnetic iron oxide nanoparticles (SPIONs) and dexamethasone 21-acetate (DXM) were co-encapsulated into biodegradable microparticles. METHODS: Poly(D,L-lactide-co-glycolide) microparticles embedding both SPIONs and DXM were prepared by a double emulsion technique. The formulation was optimized in two steps, a screening design and a full factorial design, aiming at 10-microm particle diameter and high DXM encapsulation efficacy. RESULTS: The most significant parameters were the polymer concentration, the stirring speed during solvent extraction and the extractive volume. Increasing the polymer concentration from 200 to 300 mg ml(-1), both the microparticle mean diameter and the DXM encapsulation efficacy increased up to 12 microm and 90%, respectively. The microparticles could be retained with an external magnet of 0.8 T placed at 3 mm. Faster DXM release was obtained for smaller microparticles. CONCLUSION: The experimental set-up offered the tools for tailoring a formulation with magnetic retention properties and DXM release patterns corresponding to the required specifications for intra-articular administration. | |
Keywords | Anti-Inflammatory Agents/administration & dosage — Biocompatible Materials — Chemistry, Pharmaceutical/methods — Dexamethasone/administration & dosage/analogs & derivatives — Drug Delivery Systems — Emulsions — Equipment Design — Ferric Compounds/chemistry — Injections, Intra-Articular — Magnetics — Microscopy, Electron, Scanning — Microscopy, Electron, Transmission — Microspheres — Polymers/chemistry — Time Factors | |
Identifiers | PMID: 18465308 | |
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Citation (ISO format) | BUTOESCU, Nicoleta Paula et al. Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery. In: Journal of microencapsulation, 2008, vol. 25, n° 5, p. 339-50. doi: 10.1080/02652040801999551 https://archive-ouverte.unige.ch/unige:4106 |