Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery

Butoescu, Nicoleta Paula; Jordan, Olivier; Petri-Fink, Alke; Hofmann, Heinrich; Doelker, Eric

doi:10.1080/02652040801999551

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Title		Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery
Authors		Butoescu, Nicoleta Paula Jordan, Olivier Petri-Fink, Alke Hofmann, Heinrich Doelker, Eric
Published in		Journal of Microencapsulation. 2008, vol. 25, no. 5, p. 339-50
Abstract		OBJECTIVE: Intra-articular drug delivery systems still suffer from too short-lasting effects. Magnetic particles retained in the joint using an external magnetic field might prolong the local release of an anti-inflammatory drug. For the purpose, superparamagnetic iron oxide nanoparticles (SPIONs) and dexamethasone 21-acetate (DXM) were co-encapsulated into biodegradable microparticles. METHODS: Poly(D,L-lactide-co-glycolide) microparticles embedding both SPIONs and DXM were prepared by a double emulsion technique. The formulation was optimized in two steps, a screening design and a full factorial design, aiming at 10-microm particle diameter and high DXM encapsulation efficacy. RESULTS: The most significant parameters were the polymer concentration, the stirring speed during solvent extraction and the extractive volume. Increasing the polymer concentration from 200 to 300 mg ml(-1), both the microparticle mean diameter and the DXM encapsulation efficacy increased up to 12 microm and 90%, respectively. The microparticles could be retained with an external magnet of 0.8 T placed at 3 mm. Faster DXM release was obtained for smaller microparticles. CONCLUSION: The experimental set-up offered the tools for tailoring a formulation with magnetic retention properties and DXM release patterns corresponding to the required specifications for intra-articular administration.
Keywords		Anti-Inflammatory Agents/administration & dosage — Biocompatible Materials — Chemistry, Pharmaceutical/methods — Dexamethasone/administration & dosage/analogs & derivatives — Drug Delivery Systems — Emulsions — Equipment Design — Ferric Compounds/chemistry — Injections, Intra-Articular — Magnetics — Microscopy, Electron, Scanning — Microscopy, Electron, Transmission — Microspheres — Polymers/chemistry — Time Factors
Identifiers		DOI: 10.1080/02652040801999551 PMID: 18465308
Full text		Article (Published version) (1.8 MB) - Limited access to UNIGE
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Citation (ISO format)		BUTOESCU, Nicoleta Paula et al. Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery. In: Journal of Microencapsulation, 2008, vol. 25, n° 5, p. 339-50. doi: 10.1080/02652040801999551 https://archive-ouverte.unige.ch/unige:4106