en
Scientific article
English

Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery

Published inJournal of microencapsulation, vol. 25, no. 5, p. 339-350
Publication date2008
Abstract

OBJECTIVE: Intra-articular drug delivery systems still suffer from too short-lasting effects. Magnetic particles retained in the joint using an external magnetic field might prolong the local release of an anti-inflammatory drug. For the purpose, superparamagnetic iron oxide nanoparticles (SPIONs) and dexamethasone 21-acetate (DXM) were co-encapsulated into biodegradable microparticles. METHODS: Poly(D,L-lactide-co-glycolide) microparticles embedding both SPIONs and DXM were prepared by a double emulsion technique. The formulation was optimized in two steps, a screening design and a full factorial design, aiming at 10-microm particle diameter and high DXM encapsulation efficacy. RESULTS: The most significant parameters were the polymer concentration, the stirring speed during solvent extraction and the extractive volume. Increasing the polymer concentration from 200 to 300 mg ml(-1), both the microparticle mean diameter and the DXM encapsulation efficacy increased up to 12 microm and 90%, respectively. The microparticles could be retained with an external magnet of 0.8 T placed at 3 mm. Faster DXM release was obtained for smaller microparticles. CONCLUSION: The experimental set-up offered the tools for tailoring a formulation with magnetic retention properties and DXM release patterns corresponding to the required specifications for intra-articular administration.

Keywords
  • Anti-Inflammatory Agents/administration & dosage
  • Biocompatible Materials
  • Chemistry, Pharmaceutical/methods
  • Dexamethasone/administration & dosage/analogs & derivatives
  • Drug Delivery Systems
  • Emulsions
  • Equipment Design
  • Ferric Compounds/chemistry
  • Injections, Intra-Articular
  • Magnetics
  • Microscopy, Electron, Scanning
  • Microscopy, Electron, Transmission
  • Microspheres
  • Polymers/chemistry
  • Time Factors
Citation (ISO format)
BUTOESCU, Nicoleta Paula et al. Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery. In: Journal of microencapsulation, 2008, vol. 25, n° 5, p. 339–350. doi: 10.1080/02652040801999551
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Article (Published version)
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Identifiers
ISSN of the journal0265-2048
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