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Intra-articular drug delivery systems for the treatment of rheumatic diseases: a review of the factors influencing their performance

Published inEuropean journal of pharmaceutics and biopharmaceutics, vol. 73, no. 2, p. 205-218
Publication date2009
Abstract

Osteoarthritis and rheumatoid arthritis are rheumatic diseases for which a curative treatment does not currently exist. Their management is directed towards pain relief achieved with different classes of drugs among which non-steroidal and steroidal anti-inflammatory substances are the most frequently used agents. Nevertheless, the oral or systemic administration of such drugs is hindered by numerous side effects, which could be overcome by their intra-articular (i-a.) administration as dosage forms capable of gradually releasing the active substance. The present review article summarises the research done in the field of drug delivery systems for i-a. injection vs. current management of osteoarthritis or rheumatoid arthritis. Aspects such as the influence of size, shape, polymer matrix or targeted drug on the i-a. retention time, phagocytosis and biological activity will be discussed. Finally, we will comment on the need for adapted delivery systems for the novel and very potent anti-inflammatory drugs, such as inhibitors of the p38 mitogen-activated protein kinase or the IL-1beta conversion enzyme, which to date cannot be properly used due to the severe side effects associated with their systemic administration.

Citation (ISO format)
BUTOESCU, Nicoleta Paula, JORDAN, Olivier, DOELKER, Eric. Intra-articular drug delivery systems for the treatment of rheumatic diseases: a review of the factors influencing their performance. In: European journal of pharmaceutics and biopharmaceutics, 2009, vol. 73, n° 2, p. 205–218. doi: 10.1016/j.ejpb.2009.06.009
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ISSN of the journal0939-6411
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Creation11/12/2009 1:17:00 PM
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