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High versus standard dose vancomycin for osteomyelitis

Vuagnat, Albert
Denormandie, Philippe
Published in Scandinavian Journal of Infectious Diseases. 2004, vol. 36, no. 10, p. 712-7
Abstract It is important to identify the optimal dosage and best method of infusion of parenteral vancomycin to be used over a several week period for the treatment of osteomyelitis. A retrospective study was undertaken to compare a high dose vancomycin treatment (HD: 40 mg/kg/d) with a standard dose treatment (SD: 20 mg/kg/d), and also to compare the modality of infusion using either intermittent vancomycin infusion (IVI) or continuous vancomycin infusion (CVI). 89 patients with Gram-positive cocci osteomyelitis requiring vancomycin treatment were followed, and the outcome and therapeutic safety were compared. There were significantly more adverse drug reactions (acute renal failure) in the IVI subgroup (HD-IVI vs SD-IVI, p-value 0.007). No cases of renal failure were found in the HD-CVI subgroup. The best outcome was found in the subgroup of patients who received HD-CVI (HD-CVI vs SD-IVI, overall log rank p-value 0.02). HD-CVI treatment appears to provide an improved outcome with fewer adverse drug reactions.
Keywords AgedAged, 80 and overCohort StudiesDose-Response Relationship, DrugFemaleFollow-Up StudiesGram-Positive Bacterial Infections/diagnosis/drug therapyHumansInfusions, IntravenousMaleMiddle AgedMultivariate AnalysisOsteomyelitis/drug therapy/microbiology/physiopathologyProbabilityRetrospective StudiesRisk AssessmentSeverity of Illness IndexStatistics, NonparametricTreatment OutcomeVancomycin/administration & dosage
PMID: 15513395
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Research group Chirurgie orthopédique et traumatologique (98)
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BOFFI EL AMARI, Emmanuelle Jane et al. High versus standard dose vancomycin for osteomyelitis. In: Scandinavian Journal of Infectious Diseases, 2004, vol. 36, n° 10, p. 712-7. doi: 10.1080/00365540410020901 https://archive-ouverte.unige.ch/unige:41048

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Deposited on : 2014-10-21

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