Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression
Contributeurs/tricesTrudu, Matteo; Janas, Sylvie; Lanzani, Chiara; Debaix, Huguette; Schaeffer, Céline; Ikehata, Masami; Citterio, Lorena; Demaretz, Sylvie; Trevisani, Francesco; Ristagno, Giuseppe; Glaudemans, Bob; Laghmani, Kamel; Dell'Antonio, Giacomo; Bochud, Murielle; Burnier, Michel; Martin, Pierre-Yves; Mohaupt, Markus; Paccaud, Fred; Pechere, Antoinette; Vogt, Bruno; Ackermann, Daniel; Ehret, Georg Benedikt; Guessous, Idris; Ponte, Belen; Pruijm, Menno; Loffing, Johannes; Rastaldi, Maria P; Manunta, Paolo; Devuyst, Olivier; Rampoldi, Luca
Publié dansNature medicine, vol. 19, no. 12, p. 1655-1660
Date de publication2013
Résumé
Mots-clés
- Adult
- Aged
- Animals
- Female
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Hypertension/chemically induced/genetics
- Male
- Mice
- Mice, Transgenic
- Middle Aged
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic/genetics
- Renal Insufficiency, Chronic/genetics
- Sodium, Dietary/adverse effects/pharmacokinetics
- Up-Regulation
- Uromodulin/genetics
- Young Adult
Groupe de recherche
Citation (format ISO)
TRUDU, Matteo et al. Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. In: Nature medicine, 2013, vol. 19, n° 12, p. 1655–1660. doi: 10.1038/nm.3384
Fichiers principaux (1)
Article (Published version)
Identifiants
- PID : unige:40971
- DOI : 10.1038/nm.3384
- PMID : 24185693
ISSN du journal1078-8956