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Expression of Glycophorin A, classical and non-classical MHC class I during erythropoiesis

ContributorsGonzalez, Yvan
Defense date2014
Abstract

MHC-I molecules are the principal self ligands that bind to inhibitory receptors on Natural killer cells. During erythropoiesis, HLA-A, -B and -C expression disappears but no information is available on HLA-E and HLA-G expression. Moreover, old reports state that expression of CD235a on red blood cells and their precursors confer protection from NK cell-mediated cytotoxicity. Consequently, the aim of the present study was to examine HLA-E, -G, and CD235a expression using an in vitro erythropoiesis model and bone marrow aspirates. In parallel, the expression of CD36, HLA-ABC, and CD71 was analyzed. To conclude, this thesis confirm the findings of previous studies for these markers. In addition, HLA-E and HLA-G were shown to be weakly expressed, thus it is unlikely that they play a role in NK regulation by RBCs. Furthermore, the implication of glycophorin A in NK cell regulation needs to be elucidated.

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Citation (ISO format)
GONZALEZ, Yvan. Expression of Glycophorin A, classical and non-classical MHC class I during erythropoiesis. 2014.
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Master thesis
accessLevelRestricted
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  • PID : unige:40876
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Creation10/12/2014 4:12:00 PM
First validation10/12/2014 4:12:00 PM
Update time03/14/2023 9:50:55 PM
Status update03/14/2023 9:50:55 PM
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