UNIGE document Scientific Article
previous document  unige:40856  next document
add to browser collection

Thalamic-insular dysconnectivity in schizophrenia: Evidence from structural equation modeling

Tomelleri, Luisa
Bellani, Marcella
Rambaldelli, Gianluca
Cerini, Roberto
Pozzi-Mucelli, Roberto
Balestrieri, Matteo
Tansella, Michele
show hidden authors show all authors [1 - 9]
Published in Human Brain Mapping. 2012, vol. 33, no. 3, p. 740-752
Abstract Structural and functional studies have shown that schizophrenia is often associated with frontolimbic abnormalities in the prefrontal and mediotemporal regions. It is still unclear, however, if such dysfunctional interaction extends as well to relay regions such as the thalamus and the anterior insula. Here, we measured gray matter volumes of five right-hemisphere regions in 68 patients with schizophrenia and 77 matched healthy subjects. The regions were amygdala, thalamus, and entorhinal cortex (identified as anomalous by prior studies on the same population) and dorsolateral prefrontal cortex and anterior insula (isolated by voxel-based morphometry analysis). We used structural equation modeling and found altered path coefficients connecting the thalamus to the anterior insula, the amygdala to the DLPFC, and the entorhinal cortex to the DLPFC. In particular, patients exhibited a stronger thalamus-insular connection than healthy controls. Instead, controls showed positive entorhinal-DLPFC and negative amygdalar-DLPFC connections, both of which were absent in the clinical population. Our data provide evidence that schizophrenia is characterized by an impaired right-hemisphere network, in which intrahemispheric communication involving relay structures may play a major role in sustaining the pathophysiology of the disease.
Keywords Dorsolateral prefrontal cortexAmygdalaEntorhinal cortexStructural equation modelingVoxel-based morphometry
PMID: 21484952
Full text
Article (Published version) (903 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Affective sciences
(ISO format)
CORRADI DELL'ACQUA, Corrado et al. Thalamic-insular dysconnectivity in schizophrenia: Evidence from structural equation modeling. In: Human Brain Mapping, 2012, vol. 33, n° 3, p. 740-752. doi: 10.1002/hbm.21246 https://archive-ouverte.unige.ch/unige:40856

389 hits

0 download


Deposited on : 2014-10-13

Export document
Format :
Citation style :