Hypocomplementemic urticarial vasculitis or systemic lupus erythematosus?
|Published in||American Journal of Kidney Diseases. 1999, vol. 34, no. 4, p. 745-51|
|Abstract||The 2 patients presented here showed the typical signs of hypocomplementemic urticarial vasculitis syndrome (HUVS). During follow-up, there was an inverse correlation between anti-C1q autoantibody titer and C1q antigen concentration in serum in both patients over a period of 2 years. The first patient had nephritis characterized by immune deposits in glomeruli and around the tubules. The histological findings, C1q deposits, and presence of tubuloreticular inclusions in capillary endothelial cells suggested a disease process identical to systemic lupus erythematosus (SLE). The second patient, after a lag phase of 2 years, fulfilled a fourth American College of Rheumatology criteria for SLE when she developed anti-double-stranded DNA antibodies. HUVS and SLE overlap, and the criteria for identifying HUVS as an entity distinct from SLE are lacking.|
|Keywords||Adult — Autoimmune Diseases/diagnosis/immunology/pathology — Biopsy — Complement C1q/deficiency/immunology — Diagnosis, Differential — Female — Humans — Kidney Glomerulus/immunology/pathology — Lupus Erythematosus, Systemic/diagnosis/immunology/pathology — Lupus Nephritis/diagnosis/immunology/pathology — Microscopy, Electron — Microscopy, Fluorescence — Vasculitis, Leukocytoclastic, Cutaneous/diagnosis/immunology/pathology|
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|Research group||Analyse protéomique et Analyse génomique des maladies rénales (659)|
|TRENDELENBURG, M et al. Hypocomplementemic urticarial vasculitis or systemic lupus erythematosus?. In: American Journal of Kidney Diseases, 1999, vol. 34, n° 4, p. 745-51. https://archive-ouverte.unige.ch/unige:40849|