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Title

Hypocomplementemic urticarial vasculitis or systemic lupus erythematosus?

Authors
Trendelenburg, M
Courvoisier, S
Späth, P J
Mihatsch, M
Itin, P
Schifferli, J A
Published in American Journal of Kidney Diseases. 1999, vol. 34, no. 4, p. 745-51
Abstract The 2 patients presented here showed the typical signs of hypocomplementemic urticarial vasculitis syndrome (HUVS). During follow-up, there was an inverse correlation between anti-C1q autoantibody titer and C1q antigen concentration in serum in both patients over a period of 2 years. The first patient had nephritis characterized by immune deposits in glomeruli and around the tubules. The histological findings, C1q deposits, and presence of tubuloreticular inclusions in capillary endothelial cells suggested a disease process identical to systemic lupus erythematosus (SLE). The second patient, after a lag phase of 2 years, fulfilled a fourth American College of Rheumatology criteria for SLE when she developed anti-double-stranded DNA antibodies. HUVS and SLE overlap, and the criteria for identifying HUVS as an entity distinct from SLE are lacking.
Keywords AdultAutoimmune Diseases/diagnosis/immunology/pathologyBiopsyComplement C1q/deficiency/immunologyDiagnosis, DifferentialFemaleHumansKidney Glomerulus/immunology/pathologyLupus Erythematosus, Systemic/diagnosis/immunology/pathologyLupus Nephritis/diagnosis/immunology/pathologyMicroscopy, ElectronMicroscopy, FluorescenceVasculitis, Leukocytoclastic, Cutaneous/diagnosis/immunology/pathology
Identifiers
PMID: 10516358
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Research group Analyse protéomique et Analyse génomique des maladies rénales (659)
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TRENDELENBURG, M et al. Hypocomplementemic urticarial vasculitis or systemic lupus erythematosus?. In: American Journal of Kidney Diseases, 1999, vol. 34, n° 4, p. 745-51. https://archive-ouverte.unige.ch/unige:40849

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Deposited on : 2014-10-13

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