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High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis

Trendelenburg, Marten
Lopez-Trascasa, Margarita
Potlukova, Eliska
Regenass, Stephan
Frémeaux-Bacchi, Véronique
Martinez-Ara, Jorge
Jancova, Eva
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Published in Nephrology, Dialysis, Transplantation. 2006, vol. 21, no. 11, p. 3115-21
Abstract Anti-C1q antibodies (anti-C1q) have been shown to correlate positively with systemic lupus erythematosus (SLE) nephritis. Several clinical studies indicated a high negative predictive value, suggesting that active lupus nephritis is rarely seen in patients with no anti-C1q. However, the true prevalence of anti-C1q at the time of active lupus nephritis has not been well established. The aim of this study was to determine prospectively the prevalence of anti-C1q in proven active lupus nephritis at the time of the renal biopsy.
Keywords AdultAgedAutoantibodies/bloodComplement C1q/immunologyFemaleFollow-Up StudiesHumansKidney/pathologyLupus Erythematosus, Systemic/diagnosis/immunology/pathologyLupus Nephritis/diagnosis/immunology/pathologyMaleMiddle AgedPrevalenceProspective Studies
PMID: 16877491
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Research group Analyse protéomique et Analyse génomique des maladies rénales (659)
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TRENDELENBURG, Marten et al. High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis. In: Nephrology, Dialysis, Transplantation, 2006, vol. 21, n° 11, p. 3115-21. https://archive-ouverte.unige.ch/unige:40838

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Deposited on : 2014-10-13

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