UNIGE document Scientific Article - Review
previous document  unige:40704  next document
add to browser collection
Title

Proteomics in mechanistic toxicology: history, concepts, achievements, caveats and potential

Authors
Rabilloud, Thierry
Published in Proteomics. 2014, vol. n.a.
Abstract Toxicoproteomics can be defined as the application of proteomic approaches to the understanding of toxicology problems, and this review deals with the various types of applications that have been described in the literature. Toxicoproteomics has been applied to very different classes of toxicants, from drugs and natural products to metals, or from industrial chemicals to nanoparticles and nanofibers. It has also been applied to address questions at different levels, from the search of the primary molecular targets of toxicants to the deciphering of the molecular responses of cells and tissues to toxicants. Although restricted to mammalian cells and tissues, this paper reviews these two levels of investigation and the different application areas of toxicoproteomics, leading to the discussion of the advantages and drawbacks of the most popular proteomic platforms. Some of the pending questions in toxicoproteomics are also critically addressed, such as the specificity, validation and result hierarchization issues. The question of shared mechanisms, which are encountered in many toxicoproteomic papers dealing with different toxicants, is also discussed. Finally the future of toxicoproteomics is briefly outlined. This article is protected by copyright. All rights reserved.
Identifiers
PMID: 25164579
Full text
Article (Author postprint) (1.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Chimie et protéomique clinique (270)
Citation
(ISO format)
RABILLOUD, Thierry, LESCUYER, Pierre. Proteomics in mechanistic toxicology: history, concepts, achievements, caveats and potential. In: Proteomics, 2014, vol. n.a. https://archive-ouverte.unige.ch/unige:40704

172 hits

0 download

Update

Deposited on : 2014-10-06

Export document
Format :
Citation style :