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Title

A population of glomerular glutamatergic neurons controls sensory information transfer in the mouse olfactory bulb

Authors
Seal, Rebecca P.
Edwards, Robert H.
Published in Nature Communications. 2014, vol. 5, no. 3791
Abstract In sensory systems, peripheral organs convey sensory inputs to relay networks where information is shaped by local microcircuits before being transmitted to cortical areas. In the olfactory system, odorants evoke specific patterns of sensory neuron activity that are transmitted to output neurons in olfactory bulb (OB) glomeruli. How sensory information is transferred and shaped at this level remains still unclear. Here we employ mouse genetics, 2-photon microscopy, electrophysiology and optogenetics, to identify a novel population of glutamatergic neurons (VGLUT3þ) in the glomerular layer of the adult mouse OB as well as several of their synaptic targets. Both peripheral and serotoninergic inputs control VGLUT3þ neurons firing. Furthermore, we show that VGLUT3þ neuron photostimulation in vivo strongly suppresses both spontaneous and odour-evoked firing of bulbar output neurons. In conclusion, we identify and characterize here a microcircuit controlling the transfer of sensory information at an early stage of the olfactory pathway.
Keywords OptogeneticTransgenic miceVesicular glutamate transporterOlfaction
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Research groups Groupe Carleton Alan (neurosciences fondamentales) (876)
Groupe Rodriguez
Projects FNS: PP0033_119169 and PP00P3_139189
ERC-2009-StG-243344-NEUROCHEMS
Citation
(ISO format)
TATTI, Roberta et al. A population of glomerular glutamatergic neurons controls sensory information transfer in the mouse olfactory bulb. In: Nature Communications, 2014, vol. 5, n° 3791. https://archive-ouverte.unige.ch/unige:40593

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Deposited on : 2014-09-30

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