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Scientific article
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English

Long term functional plasticity of sensory inputs mediated by olfactory learning

Contributors

Abraham, Nixon; Vincis, Roberto; Lagier, Samuel; Rodriguez, Ivan; Carleton, Alan

Published in

eLife, vol. 3, no. e02109

Publication date

2014

Abstract

Sensory inputs are remarkably organized along all sensory pathways. While sensory representations are known to undergo plasticity at the higher levels of sensory pathways following peripheral lesions or sensory experience, less is known about the functional plasticity of peripheral inputs induced by learning. We addressed this question in the adult mouse olfactory system by combining odor discrimination studies with functional imaging of sensory input activity in awake mice. Here we show that associative learning, but not passive odor exposure, potentiates the strength of sensory inputs up to several weeks after the end of training. We conclude that experience-dependent plasticity can occur in the periphery of adult mouse olfactory system, which should improve odor detection and contribute towards accurate and fast odor discriminations.

Keywords

  • Bahavior
  • Functional imaging
  • Mouse olfaction
  • Associative learning
  • Plasticity

UNIGE affiliation entities

UNIGE research groups

Funding

Citation (ISO format)

ABRAHAM, Nixon et al. Long term functional plasticity of sensory inputs mediated by olfactory learning. In: eLife, 2014, vol. 3, n° e02109. doi: 10.7554/eLife.02109

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

2050-084X
731views
337downloads

Technical informations

Creation

29/09/2014 11:31:00

First validation

29/09/2014 11:31:00

Update

13/10/2025 22:22:00

Status update

05/08/2025 13:27:35

Last indexation

02/11/2026 16:38:26
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