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Scientific article
Open access
English

Long term functional plasticity of sensory inputs mediated by olfactory learning

Published ineLife, vol. 3, no. e02109
Publication date2014
Abstract

Sensory inputs are remarkably organized along all sensory pathways. While sensory representations are known to undergo plasticity at the higher levels of sensory pathways following peripheral lesions or sensory experience, less is known about the functional plasticity of peripheral inputs induced by learning. We addressed this question in the adult mouse olfactory system by combining odor discrimination studies with functional imaging of sensory input activity in awake mice. Here we show that associative learning, but not passive odor exposure, potentiates the strength of sensory inputs up to several weeks after the end of training. We conclude that experience-dependent plasticity can occur in the periphery of adult mouse olfactory system, which should improve odor detection and contribute towards accurate and fast odor discriminations.

Keywords
  • Bahavior
  • Functional imaging
  • Mouse olfaction
  • Associative learning
  • Plasticity
Funding
  • Swiss National Science Foundation - PP0033_119169, PP00P3_139189
  • European Commission - From neurons to behavior: analysis of the mechanisms underlying sensory coding and plasticity in chemical senses [243344]
Citation (ISO format)
ABRAHAM, Nixon et al. Long term functional plasticity of sensory inputs mediated by olfactory learning. In: eLife, 2014, vol. 3, n° e02109. doi: 10.7554/eLife.02109
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal2050-084X
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228downloads

Technical informations

Creation09/29/2014 11:31:00 AM
First validation09/29/2014 11:31:00 AM
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