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Title

Multimeric tyrosine sulfate acts as an endothelial cell protectant and prevents complement activation in xenotransplantation models

Authors
Walpen, Alexander J
Matozan, Katja M
Korchagina, Elena Y
Bovin, Nicolai V
Haeberli, André
Mohacsi, Paul J
Rieben, Robert
Published in Xenotransplantation. 2004, vol. 11, no. 3, p. 262-8
Abstract Activation of endothelial cells (EC) in xenotransplantation is mostly induced through binding of antibodies (Ab) and activation of the complement system. Activated EC lose their heparan sulfate proteoglycan (HSPG) layer and exhibit a procoagulant and pro-inflammatory cell surface. We have recently shown that the semi-synthetic proteoglycan analog dextran sulfate (DXS, MW 5000) blocks activation of the complement cascade and acts as an EC-protectant both in vitro and in vivo. However, DXS is a strong anticoagulant and systemic use of this substance in a clinical setting might therefore be compromised. It was the aim of this study to investigate a novel, fully synthetic EC-protectant with reduced inhibition of the coagulation system.
Keywords AdultAnimalsAortaBlood Component TransfusionCell Culture TechniquesComplement Activation/drug effects/immunologyComplement Inactivator Proteins/pharmacologyEndothelium, Vascular/cytology/drug effects/immunologyHemolysisHumansPartial Thromboplastin TimeSerum/immunologySwineTransplantation, Heterologous/immunologyTyrosine/analogs & derivatives/pharmacology
Identifiers
PMID: 15099206
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LAUMONIER, Thomas et al. Multimeric tyrosine sulfate acts as an endothelial cell protectant and prevents complement activation in xenotransplantation models. In: Xenotransplantation, 2004, vol. 11, n° 3, p. 262-8. https://archive-ouverte.unige.ch/unige:40455

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Deposited on : 2014-09-24

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