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Scientific article
English

Multimeric tyrosine sulfate acts as an endothelial cell protectant and prevents complement activation in xenotransplantation models

Published inXenotransplantation, vol. 11, no. 3, p. 262-268
Publication date2004
Abstract

Activation of endothelial cells (EC) in xenotransplantation is mostly induced through binding of antibodies (Ab) and activation of the complement system. Activated EC lose their heparan sulfate proteoglycan (HSPG) layer and exhibit a procoagulant and pro-inflammatory cell surface. We have recently shown that the semi-synthetic proteoglycan analog dextran sulfate (DXS, MW 5000) blocks activation of the complement cascade and acts as an EC-protectant both in vitro and in vivo. However, DXS is a strong anticoagulant and systemic use of this substance in a clinical setting might therefore be compromised. It was the aim of this study to investigate a novel, fully synthetic EC-protectant with reduced inhibition of the coagulation system.

Keywords
  • Adult
  • Animals
  • Aorta
  • Blood Component Transfusion
  • Cell Culture Techniques
  • Complement Activation/drug effects/immunology
  • Complement Inactivator Proteins/pharmacology
  • Endothelium, Vascular/cytology/drug effects/immunology
  • Hemolysis
  • Humans
  • Partial Thromboplastin Time
  • Serum/immunology
  • Swine
  • Transplantation, Heterologous/immunology
  • Tyrosine/analogs & derivatives/pharmacology
Affiliation Not a UNIGE publication
Citation (ISO format)
LAUMONIER, Thomas et al. Multimeric tyrosine sulfate acts as an endothelial cell protectant and prevents complement activation in xenotransplantation models. In: Xenotransplantation, 2004, vol. 11, n° 3, p. 262–268. doi: 10.1111/j.1399-3089.2004.00125.x
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0908-665X
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