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Title

Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells

Authors
Walpen, Alexander J
Maurus, Christine F
Mohacsi, Paul J
Matozan, Katja M
Korchagina, Elena Y
Bovin, Nicolai V
Vanhove, Bernard
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Published in Transplantation. 2003, vol. 76, no. 5, p. 838-43
Abstract The innate immune system, including complement and natural killer (NK) cells, plays a critical role in activation and damage of endothelial cells (ECs) during xenograft rejection. The semisynthetic proteoglycan analog dextran sulfate (DXS, molecular weight 5,000) is known to inhibit the complement and coagulation cascades. We hypothesized that DXS may act as an "EC-protectant" preventing complement and NK lysis by functionally replacing heparan sulfate proteoglycans that are shed from the EC surface on activation of the endothelium.
Keywords AnimalsAnticoagulants/metabolism/pharmacologyAorta/cytologyBlood Proteins/pharmacologyCells, CulturedComplement Activation/drug effectsComplement Inactivator Proteins/pharmacologyDextran Sulfate/metabolism/pharmacologyDose-Response Relationship, DrugEndothelium, Vascular/cytology/drug effects/immunologyGraft Rejection/drug therapy/immunologyHeparin Lyase/pharmacologyHumansKiller Cells, Natural/drug effects/immunologySwineTransplantation, Heterologous/immunology
Identifiers
PMID: 14501864
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LAUMONIER, Thomas et al. Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells. In: Transplantation, 2003, vol. 76, n° 5, p. 838-43. https://archive-ouverte.unige.ch/unige:40448

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Deposited on : 2014-09-24

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