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Scientific article
English

Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells

Published inTransplantation, vol. 76, no. 5, p. 838-843
Publication date2003
Abstract

The innate immune system, including complement and natural killer (NK) cells, plays a critical role in activation and damage of endothelial cells (ECs) during xenograft rejection. The semisynthetic proteoglycan analog dextran sulfate (DXS, molecular weight 5,000) is known to inhibit the complement and coagulation cascades. We hypothesized that DXS may act as an "EC-protectant" preventing complement and NK lysis by functionally replacing heparan sulfate proteoglycans that are shed from the EC surface on activation of the endothelium.

Keywords
  • Animals
  • Anticoagulants/metabolism/pharmacology
  • Aorta/cytology
  • Blood Proteins/pharmacology
  • Cells, Cultured
  • Complement Activation/drug effects
  • Complement Inactivator Proteins/pharmacology
  • Dextran Sulfate/metabolism/pharmacology
  • Dose-Response Relationship, Drug
  • Endothelium, Vascular/cytology/drug effects/immunology
  • Graft Rejection/drug therapy/immunology
  • Heparin Lyase/pharmacology
  • Humans
  • Killer Cells, Natural/drug effects/immunology
  • Swine
  • Transplantation, Heterologous/immunology
Affiliation Not a UNIGE publication
Citation (ISO format)
LAUMONIER, Thomas et al. Dextran sulfate acts as an endothelial cell protectant and inhibits human complement and natural killer cell-mediated cytotoxicity against porcine cells. In: Transplantation, 2003, vol. 76, n° 5, p. 838–843. doi: 10.1097/01.TP.0000078898.28399.0A
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0041-1337
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