• Home
  1. Home
  2. Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations
Scientific article
English

Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations

Contributors

Ganesh, Santhi K; Ehret, Georg Benedikt; Global Blood Pressure Genetics Consortium

Published in

American journal of human genetics, vol. 95, no. 1, p. 49-65

Publication date

2014

Abstract

Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby increase statistical power to detect genetic associations. We studied systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) averaged over multiple years in 46,629 individuals of European ancestry. We identified 39 trait-variant associations across 19 independent loci (p < 5 × 10(-8)); five associations (in four loci) uniquely identified by our LTA analyses included those of SBP and MAP at 2p23 (rs1275988, near KCNK3), DBP at 2q11.2 (rs7599598, in FER1L5), and PP at 6p21 (rs10948071, near CRIP3) and 7p13 (rs2949837, near IGFBP3). Replication analyses conducted in cohorts with single-visit BP data showed positive replication of associations and a nominal association (p < 0.05). We estimated a 20% gain in statistical power with long-term average (LTA) as compared to single-visit BP association studies. Using LTA analysis, we identified genetic loci influencing BP. LTA might be one way of increasing the power of genetic associations for continuous traits in extant samples for other phenotypes that are measured serially over time.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

GANESH, Santhi K, EHRET, Georg Benedikt. Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. In: American journal of human genetics, 2014, vol. 95, n° 1, p. 49–65. doi: 10.1016/j.ajhg.2014.06.002

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0002-9297
657views
3downloads

Technical informations

Creation

23/08/2014 22:52:00

First validation

23/08/2014 22:52:00

Update

13/10/2025 22:23:24

Status update

24/01/2025 14:00:03

Last indexation

10/11/2026 17:09:07
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated