en
Scientific article
Open access
English

PROSITE: a documented database using patterns and profiles as motif descriptors

Published inBriefings in bioinformatics, vol. 3, no. 3, p. 265-274
Publication date2002
Abstract

Among the various databases dedicated to the identification of protein families and domains, PROSITE is the first one created and has continuously evolved since. PROSITE currently consists of a large collection of biologically meaningful motifs that are described as patterns or profiles, and linked to documentation briefly describing the protein family or domain they are designed to detect. The close relationship of PROSITE with the SWISS-PROT protein database allows the evaluation of the sensitivity and specificity of the PROSITE motifs and their periodic reviewing. In return, PROSITE is used to help annotate SWISS-PROT entries. The main characteristics and the techniques of family and domain identification used by PROSITE are reviewed in this paper.

Keywords
  • Amino Acid Motifs
  • Amino Acid Sequence
  • Computational Biology
  • Databases, Protein
  • Internet
  • Models, Molecular
  • Protein Structure, Tertiary
  • Proteins/chemistry/classification/genetics
  • Sequence Alignment
  • Software
Citation (ISO format)
SIGRIST, Christian et al. PROSITE: a documented database using patterns and profiles as motif descriptors. In: Briefings in bioinformatics, 2002, vol. 3, n° 3, p. 265–274. doi: 10.1093/bib/3.3.265
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1467-5463
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Technical informations

Creation08/08/2014 5:43:00 PM
First validation08/08/2014 5:43:00 PM
Update time03/30/2023 10:26:34 AM
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