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Scientific article
English

Activity-dependent structural plasticity of perisynaptic astrocytic domains promotes excitatory synapse stability

Published inCurrent biology, vol. 24, no. 15, p. 1679-1688
Publication date2014
Abstract

Excitatory synapses in the CNS are highly dynamic structures that can show activity-dependent remodeling and stabilization in response to learning and memory. Synapses are enveloped with intricate processes of astrocytes known as perisynaptic astrocytic processes (PAPs). PAPs are motile structures displaying rapid actin-dependent movements and are characterized by Ca(2+) elevations in response to neuronal activity. Despite a debated implication in synaptic plasticity, the role of both Ca(2+) events in astrocytes and PAP morphological dynamics remain unclear.

Citation (ISO format)
BERNARDINELLI, Yann et al. Activity-dependent structural plasticity of perisynaptic astrocytic domains promotes excitatory synapse stability. In: Current biology, 2014, vol. 24, n° 15, p. 1679–1688. doi: 10.1016/j.cub.2014.06.025
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ISSN of the journal0960-9822
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Creation08/12/2014 9:59:00 AM
First validation08/12/2014 9:59:00 AM
Update time03/14/2023 9:46:38 PM
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