• Home
  1. Home
  2. Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia
Scientific article
English

Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia

Contributors

Noris, Patrizia; Lecompte, Thomas Pierre; Boehlen, Françoise; Fontana, Pierre

Published in

Haematologica, vol. 99, no. 8, p. 1387-1394

Publication date

2014

Abstract

Pregnancy in women with inherited thrombocytopenias is a major matter of concern as both the mothers and the newborns are potentially at risk of bleeding. However, medical management of this condition cannot be based on evidence because of the lack of consistent information in the literature. To advance knowledge on this matter, we performed a multicentric, retrospective study evaluating 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia. Neither the degree of thrombocytopenia nor the severity of bleeding tendency worsened during pregnancy and the course of pregnancy did not differ from that of healthy subjects in terms of miscarriages, fetal bleeding and pre-term births. The degree of thrombocytopenia in the babies was similar to that in the mother. Only 7 of 156 affected newborns had delivery-related bleeding, but 2 of them died of cerebral hemorrhage. The frequency of delivery-related maternal bleeding ranged from 6.8% to 14.2% depending on the definition of abnormal blood loss, suggesting that the risk of abnormal blood loss was increased with respect to the general population. However, no mother died or had to undergo hysterectomy to arrest bleeding. The search for parameters predicting delivery-related bleeding in the mother suggested that hemorrhages requiring blood transfusion were more frequent in women with history of severe bleedings before pregnancy and with platelet count at delivery below 50 × 10(9)/L.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

NORIS, Patrizia et al. Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia. In: Haematologica, 2014, vol. 99, n° 8, p. 1387–1394. doi: 10.3324/haematol.2014.105924

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0390-6078
643views
2downloads

Technical informations

Creation

02/08/2014 11:37:00

First validation

02/08/2014 11:37:00

Update

03/02/2025 11:33:00

Status update

03/02/2025 11:33:00

Last indexation

03/02/2025 11:40:04
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated