UNIGE document Scientific Article
previous document  unige:40288  next document
add to browser collection
Title

Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia

Authors
Noris, Patrizia
Schlegel, Nicole
Klersy, Catherine
Heller, Paula G
Civaschi, Elisa
Pujol-Moix, Nuria
Fabris, Fabrizio
Favier, Remi
show hidden authors show all authors [1 - 65]
Published in Haematologica. 2014, vol. 99, no. 8, p. 1387-94
Abstract Pregnancy in women with inherited thrombocytopenias is a major matter of concern as both the mothers and the newborns are potentially at risk of bleeding. However, medical management of this condition cannot be based on evidence because of the lack of consistent information in the literature. To advance knowledge on this matter, we performed a multicentric, retrospective study evaluating 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia. Neither the degree of thrombocytopenia nor the severity of bleeding tendency worsened during pregnancy and the course of pregnancy did not differ from that of healthy subjects in terms of miscarriages, fetal bleeding and pre-term births. The degree of thrombocytopenia in the babies was similar to that in the mother. Only 7 of 156 affected newborns had delivery-related bleeding, but 2 of them died of cerebral hemorrhage. The frequency of delivery-related maternal bleeding ranged from 6.8% to 14.2% depending on the definition of abnormal blood loss, suggesting that the risk of abnormal blood loss was increased with respect to the general population. However, no mother died or had to undergo hysterectomy to arrest bleeding. The search for parameters predicting delivery-related bleeding in the mother suggested that hemorrhages requiring blood transfusion were more frequent in women with history of severe bleedings before pregnancy and with platelet count at delivery below 50 × 10(9)/L.
Identifiers
PMID: 24763399
Full text
Article (Published version) (219 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Geneva Platelet Group (13)
Groupe Lecompte Thomas Pierre (hématologie) (918)
Citation
(ISO format)
NORIS, Patrizia et al. Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia. In: Haematologica, 2014, vol. 99, n° 8, p. 1387-94. https://archive-ouverte.unige.ch/unige:40288

212 hits

0 download

Update

Deposited on : 2014-09-18

Export document
Format :
Citation style :