Effect of emaciation and obesity on small-animal internal radiation dosimetry for positron-emitting radionuclides

Xie, Tianwu; Zaidi, Habib

doi:10.1007/s00259-013-2485-9

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Title		Effect of emaciation and obesity on small-animal internal radiation dosimetry for positron-emitting radionuclides
Authors		Xie, Tianwu Zaidi, Habib
Published in		European Journal of Nuclear Medicine and Molecular Imaging. 2013, vol. 40, no. 11, p. 1748-59
Abstract		Rats are widely used in biomedical research involving molecular imaging and therefore the radiation dose to animals has become a concern. The weight of laboratory animals might change through emaciation or obesity as a result of their use in various research experiments including those investigating different diet types. In this work, we evaluated the effects of changes in body weight induced by emaciation and obesity on the internal radiation dose from common positron-emitting radionuclides.
Keywords		Animals — Electrons — Emaciation/radionuclide imaging — Models, Biological — Obesity/radionuclide imaging — Radioisotopes/pharmacokinetics — Radiometry — Rats — Tissue Distribution
Identifiers		DOI: 10.1007/s00259-013-2485-9 PMID: 23817685
Full text		Article (Published version) (1.3 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research group		Imagerie Médicale (TEP et TEMP) (542)
Project		FNS: 31003A-149957
Citation (ISO format)		XIE, Tianwu, ZAIDI, Habib. Effect of emaciation and obesity on small-animal internal radiation dosimetry for positron-emitting radionuclides. In: European Journal of Nuclear Medicine and Molecular Imaging, 2013, vol. 40, n° 11, p. 1748-59. doi: 10.1007/s00259-013-2485-9 https://archive-ouverte.unige.ch/unige:40171