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Scientific article
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English

Effect of emaciation and obesity on small-animal internal radiation dosimetry for positron-emitting radionuclides

Published inEuropean journal of nuclear medicine and molecular imaging, vol. 40, no. 11, p. 1748-1759
Publication date2013
Abstract

Rats are widely used in biomedical research involving molecular imaging and therefore the radiation dose to animals has become a concern. The weight of laboratory animals might change through emaciation or obesity as a result of their use in various research experiments including those investigating different diet types. In this work, we evaluated the effects of changes in body weight induced by emaciation and obesity on the internal radiation dose from common positron-emitting radionuclides.

Keywords
  • Animals
  • Electrons
  • Emaciation/radionuclide imaging
  • Models, Biological
  • Obesity/radionuclide imaging
  • Radioisotopes/pharmacokinetics
  • Radiometry
  • Rats
  • Tissue Distribution
Citation (ISO format)
XIE, Tianwu, ZAIDI, Habib. Effect of emaciation and obesity on small-animal internal radiation dosimetry for positron-emitting radionuclides. In: European journal of nuclear medicine and molecular imaging, 2013, vol. 40, n° 11, p. 1748–1759. doi: 10.1007/s00259-013-2485-9
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1619-7070
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