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Title

Age-dependent small-animal internal radiation dosimetry

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Published in Molecular Imaging. 2013, vol. 12, no. 6, p. 364-75
Abstract Rats at various ages were observed to present with different radiosensitivity and bioavailability for radiotracers commonly used in preclinical research. We evaluated the effect of age-induced changes in body weight on radiation dose calculations. A series of rat models at different age periods were constructed based on the realistic four-dimensional digital rat whole-body (ROBY) computational model. Particle transport was simulated using the MCNPX Monte Carlo code. Absorbed fractions (AFs) and specific absorbed fraction (SAFs) of monoenergetic photons/electrons and S values of eight positron-emitting radionuclides were calculated. The SAFs and S values for most source-target pairs were inversely correlated with body weight. Differences between F-18 S values for most source-target pairs were between -1.5% and -2%/10 g difference in body weight for different computational models. For specific radiotracers, the radiation dose to organs presents a negative correlation with rat body weight. The SAFs for monoenergetic photons/electrons and S values for common positron-emitting radionuclides can be exploited in the assessment of radiation dose delivered to rats at different ages and weights. The absorbed dose to organs is significantly higher in the low-weight young rat model than in the adult model, which would result in steep secondary effects and might be a noteworthy issue in laboratory animal internal dosimetry.
Keywords Age FactorsAnimalsBody WeightComputer SimulationDisease Models, AnimalKidney/physiologyModels, BiologicalMonte Carlo MethodOrgan SizeRadiometry/methodsRatsRats, WistarStomach/physiology
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PMID: 23981782
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Article (Published version) (2.7 MB) - public document Free access
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Research group Imagerie Médicale (TEP et TEMP) (542)
Project FNS: 31003A-149957
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(ISO format)
XIE, Tianwu, ZAIDI, Habib. Age-dependent small-animal internal radiation dosimetry. In: Molecular Imaging, 2013, vol. 12, n° 6, p. 364-75. https://archive-ouverte.unige.ch/unige:40167

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Deposited on : 2014-09-12

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