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Amyloid-β positron emission tomography imaging probes: a critical review

Kepe, Vladimir
Moghbel, Mateen C
Långström, Bengt
Vinters, Harry V
Huang, Sung-Cheng
Satyamurthy, Nagichettiar
Doudet, Doris
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Published in Journal of Alzheimer's Disease. 2013, vol. 36, no. 4, p. 613-31
Abstract The rapidly rising prevalence and cost of Alzheimer's disease in recent decades has made the imaging of amyloid-β deposits the focus of intense research. Several amyloid imaging probes with purported specificity for amyloid-β plaques are currently at various stages of FDA approval. However, a number of factors appear to preclude these probes from clinical utilization. As the available "amyloid specific" positron emission tomography imaging probes have failed to demonstrate diagnostic value and have shown limited utility for monitoring therapeutic interventions in humans, a debate on their significance has emerged. The aim of this review is to identify and discuss critically the scientific issues contributing to the extensive inconsistencies reported in the literature on their purported in vivo amyloid specificity and potential utilization in patients.
Keywords Alzheimer Disease/radionuclide imagingAmyloid beta-Peptides/diagnostic useAnimalsBrain/radionuclide imagingHumansPositron-Emission Tomography/methodsRadioisotopes/diagnostic useSensitivity and Specificity
PMID: 23648516
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Research group Imagerie Médicale (TEP et TEMP) (542)
Project FNS: 31003A-149957
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KEPE, Vladimir et al. Amyloid-β positron emission tomography imaging probes: a critical review. In: Journal of Alzheimer's Disease, 2013, vol. 36, n° 4, p. 613-31. doi: 10.3233/JAD-130485 https://archive-ouverte.unige.ch/unige:40165

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Deposited on : 2014-09-12

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