en
Scientific article
English

Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes

Published inJournal of hepatology, vol. 43, no. 6, p. 1031-1037
Publication date2005
Abstract

Liver failure is a life threatening condition currently treated by palliative measures and, when applicable, organ transplantation. The use of a bioartificial organ capable of fulfilling the main functions of the liver would represent an attractive alternative. However, the shortage of suitable donor cells, and their limited growth ability have impeded the development of this strategy. We investigated whether lentiviral vectors allow for conditional immortalization of human hepatocytes and whether these immortalized hepatocytes could reverse lethal acute liver failure.

Keywords
  • Acetaminophen/adverse effects
  • Adult
  • Analgesics, Non-Narcotic/adverse effects
  • Animals
  • Cell Line, Transformed
  • Cell Transplantation/methods
  • Disease Models, Animal
  • Genetic Vectors
  • Hepatocytes/transplantation
  • Humans
  • Lentivirus
  • Liver Failure, Acute/chemically induced/therapy
  • Liver, Artificial
  • Mice
Citation (ISO format)
NGUYEN, Tuan Huy et al. Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes. In: Journal of hepatology, 2005, vol. 43, n° 6, p. 1031–1037. doi: 10.1016/j.jhep.2005.05.036
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Article (Published version)
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ISSN of the journal0168-8278
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