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Title

Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes

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Published in Journal of Hepatology. 2005, vol. 43, no. 6, p. 1031-7
Abstract Liver failure is a life threatening condition currently treated by palliative measures and, when applicable, organ transplantation. The use of a bioartificial organ capable of fulfilling the main functions of the liver would represent an attractive alternative. However, the shortage of suitable donor cells, and their limited growth ability have impeded the development of this strategy. We investigated whether lentiviral vectors allow for conditional immortalization of human hepatocytes and whether these immortalized hepatocytes could reverse lethal acute liver failure.
Keywords Acetaminophen/adverse effectsAdultAnalgesics, Non-Narcotic/adverse effectsAnimalsCell Line, TransformedCell Transplantation/methodsDisease Models, AnimalGenetic VectorsHepatocytes/transplantationHumansLentivirusLiver Failure, Acute/chemically induced/therapyLiver, ArtificialMice
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PMID: 16169114
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Article (Published version) (329 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research groups Chirurgie viscérale (104)
Cultures cellulaires et transplantations (519)
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NGUYEN, Tuan Huy et al. Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes. In: Journal of Hepatology, 2005, vol. 43, n° 6, p. 1031-7. https://archive-ouverte.unige.ch/unige:39994

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Deposited on : 2014-09-05

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