Upregulation of CD40, CD80, CD83 or CD86 on alveolar macrophages after lung transplantation

Nicod, Laurent; Joudrier-Messmer, Sylvia; Isler, Patrick; Spiliopoulos, Anastase; Pache, Jean-Claude

doi:10.1016/j.healun.2004.07.011

Scientific article

English

Upregulation of CD40, CD80, CD83 or CD86 on alveolar macrophages after lung transplantation

ContributorsNicod, Laurent; Joudrier-Messmer, Sylvia; Isler, Patrick; Spiliopoulos, Anastase; Pache, Jean-Claude

Published inThe Journal of heart and lung transplantation, vol. 24, no. 8, p. 1067-1075

Publication date2005

Abstract

Alveolar macrophages (AMs) are known to be poor antigen-presenting cells, and lack the accessory molecules such as CD40, CD80 or CD86 to activate T cells. The question raised is about the potential changes in phenotypes after lung transplantation, particularly during acute rejection episodes.

Keywords

Adult
Aged
Antigens, CD/analysis
Antigens, CD40/analysis
Antigens, CD86/analysis
Biological Markers/analysis
Bronchoalveolar Lavage Fluid/cytology
Case-Control Studies
Female
Flow Cytometry
Graft Rejection
Graft Survival
Humans
Immunoglobulins/analysis
Immunohistochemistry
Lung Transplantation/adverse effects/immunology
Macrophages, Alveolar/cytology
Male
Membrane Glycoproteins/analysis
Middle Aged
Prognosis
Reference Values
Retrospective Studies
Sensitivity and Specificity
Transplantation Immunology/physiology
Up-Regulation

Affiliation entities

Research groups

Groupe Pache Jean-Claude (pathologie clinique) (658)

Citation (ISO format)

NICOD, Laurent et al. Upregulation of CD40, CD80, CD83 or CD86 on alveolar macrophages after lung transplantation. In: The Journal of heart and lung transplantation, 2005, vol. 24, n° 8, p. 1067–1075. doi: 10.1016/j.healun.2004.07.011

Article (Published version)

Identifiers

PID : unige:39992
DOI : 10.1016/j.healun.2004.07.011
PMID : 16102442

Journal ISSN1053-2498

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Upregulation of CD40, CD80, CD83 or CD86 on alveolar macrophages after lung transplantation

Alveolar macrophages (AMs) are known to be poor antigen-presenting cells, and lack the accessory molecules such as CD40, CD80 or CD86 to activate T cells. The question raised is about the potential changes in phenotypes after lung transplantation, particularly during acute rejection episodes.

Technical informations