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On-line and At-line Liquid Chromatography Nuclear Magnetic Resonance and Related Micro-Nuclear Magnetic Resonance Methods in Natural Product Analysis

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Published in K. Hostettmann, S. Chen, A. Marston, H. Stuppner. Encyclopedia of Analytical Chemistry. Chichester, UK: Wiley. 2014
Abstract Nuclear magnetic resonance spectroscopy (NMR) is essential for the de novo structure identification of natural products. This technique can be directly or indirectly hyphenated to high performance liquid chromatography (HPLC) leading to efficient LC-NMR platforms. NMR is, however, a very insensitive detection method compared to mass spectrometry and several strategies for its efficient hyphenation with HPLC have been developed. This includes on-line LC-NMR, SPE-NMR, or other at-line approaches involving microflow probes or microtubes in combination with cryoprobes. All of these various technologies and their potentials and limitations in the field of natural product research are described. Recent applications involving other complementary detection methods such as LC-MS or biological HPLC profiling illustrate its utilization.
Keywords LC-NMRSPE-NMRMicroflow NMRMicro-NMRCryo-NMRNatural productsPhytochemical analysisDereplicationMetabolite profiling
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Book chapter (Published version) (1.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Phytochimie et produits naturels bioactifs
Projects FNS: CRSII3_127187
FNS: 205320-124667/1
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BOHNI, Nadine, FERREIRA QUEIROZ, Emerson, WOLFENDER, Jean-Luc. On-line and At-line Liquid Chromatography Nuclear Magnetic Resonance and Related Micro-Nuclear Magnetic Resonance Methods in Natural Product Analysis. In: K. Hostettmann, S. Chen, A. Marston, H. Stuppner (Ed.). Encyclopedia of Analytical Chemistry. Chichester, UK : Wiley, 2014. https://archive-ouverte.unige.ch/unige:39953

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Deposited on : 2014-09-03

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