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Obstetrical Antiphospholipid Syndrome: From the Pathogenesis to the Clinical and Therapeutic Implications

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Published in Clinical and Developmental Immunology. 2013, vol. 2013, p. 1-9
Abstract Antiphospholipid syndrome (APS) is an acquired thrombophilia with clinical manifestations associated with the presence of antiphospholipid antibodies (aPL) in patient plasma. Obstetrical APS is a complex entity that may affect both mother and fetus throughout the entire pregnancy with high morbidity. Clinical complications are as various as recurrent fetal losses, stillbirth, intrauterine growth restriction (IUGR), and preeclampsia. Pathogenesis of aPL targets trophoblastic cells directly, mainly via proapoptotic, proinflammatory mechanisms, and uncontrolled immunomodulatory responses. Actual first-line treatment is limited to low-dose aspirin (LDA) and low-molecular weight heparin (LMWH) and still failed in 30% of the cases. APS pregnancies should be a major field in obstetrical research, and new therapeutics are still in progress.
Keywords AntiphospholipidTrophoblastObstetrical
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PMID: 23983765
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Article (Published version) (1.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.hindawi.com/journals/jir/2013/159124/
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Research group Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
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MARCHETTI, Tess, COHEN, Marie-Benoîte, DE MOERLOOSE, Philippe. Obstetrical Antiphospholipid Syndrome: From the Pathogenesis to the Clinical and Therapeutic Implications. In: Clinical and Developmental Immunology, 2013, vol. 2013, p. 1-9. https://archive-ouverte.unige.ch/unige:39900

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Deposited on : 2014-09-02

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