UNIGE document Scientific Article
previous document  unige:39900  next document
add to browser collection
Title

Obstetrical Antiphospholipid Syndrome: From the Pathogenesis to the Clinical and Therapeutic Implications
Authors
Marchetti, Tess
Cohen, Marie-Benoîte
De Moerloose, Philippe
Published in Clinical and Developmental Immunology. 2013, vol. 2013, p. 1-9
Abstract Antiphospholipid syndrome (APS) is an acquired thrombophilia with clinical manifestations associated with the presence of antiphospholipid antibodies (aPL) in patient plasma. Obstetrical APS is a complex entity that may affect both mother and fetus throughout the entire pregnancy with high morbidity. Clinical complications are as various as recurrent fetal losses, stillbirth, intrauterine growth restriction (IUGR), and preeclampsia. Pathogenesis of aPL targets trophoblastic cells directly, mainly via proapoptotic, proinflammatory mechanisms, and uncontrolled immunomodulatory responses. Actual first-line treatment is limited to low-dose aspirin (LDA) and low-molecular weight heparin (LMWH) and still failed in 30% of the cases. APS pregnancies should be a major field in obstetrical research, and new therapeutics are still in progress.
Keywords Antiphospholipid — Trophoblast — Obstetrical
Identifiers
PMID: 23983765
Full text
Article (Published version) (1.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.hindawi.com/journals/jir/2013/159124/
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Faculté de médecine / Section de médecine clinique / Département de gynécologie et d'obstétrique
Research group Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
Citation
(ISO format) 		MARCHETTI, Tess, COHEN, Marie-Benoîte, DE MOERLOOSE, Philippe. Obstetrical Antiphospholipid Syndrome: From the Pathogenesis to the Clinical and Therapeutic Implications. In: Clinical and Developmental Immunology, 2013, vol. 2013, p. 1-9. https://archive-ouverte.unige.ch/unige:39900

229 hits

2 downloads

Contact an author

Update request

Update

Deposited on : 2014-09-02

Export document
Format :
Citation style :