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Title

Validation of a dropout assessment model of candidates with/without hepatocellular carcinoma on a common liver transplant waiting list

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Published in Transplant International. 2014, vol. 27, no. 7, p. 686-95
Abstract The model of end-stage liver disease (MELD) score is often used for liver graft allocation, and patients with hepatocellular carcinoma (HCC) receive exception points (22 in the US). A better model is desirable for patients with HCC as they tend to have a privileged access to transplantation, without taking HCC characteristics into account. A new simpler model designed from a training set of US patients (n = 49 026) was tested on two validation sets (US and UK patient cohorts with, respectively, n = 20 475 and n = 1781). The risk of dropout was between 3.2 and 7.8% at 3 months in patients with HCC, and was captured into a score, including HCC size, HCC number, AFP, and MELD (-37.8 +1.9*MELD+5.9 if HCC Nb ≥ 2 + 5.9 if AFP > 400 + 21.2 if HCC size > 1 cm). This new model could be validated on external US and UK liver candidate cohorts. It provides a dynamic and more accurate assessment of dropout than the use of exception MELD (C-indices of 66.2-73.7% vs. 52.7-56.6%). In addition, the model shows a similar distribution as MELD for patients with non-HCC, and both scores could be used in parallel for the management of waiting-list patients with and without HCC.
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PMID: 24649861
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Article (Published version) (161 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Transplantation et hépatologie (905)
Hépatologie chirurgicale (327)
La transplantation d'îlots de Langerhans (623)
Chirurgie viscérale (104)
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TOSO, Christian et al. Validation of a dropout assessment model of candidates with/without hepatocellular carcinoma on a common liver transplant waiting list. In: Transplant International, 2014, vol. 27, n° 7, p. 686-95. https://archive-ouverte.unige.ch/unige:39643

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Deposited on : 2014-08-22

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