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Title

Severe left ventricular dysfunction secondary to primary pulmonary hypertension: bridging therapy with bosentan before lung transplantation

Authors
Brauchlin, Andreas
Trindade, Pedro
Published in Journal of Heart and Lung Transplantation. 2005, vol. 24, no. 6, p. 777-80
Abstract When right ventricular failure develops secondary to primary pulmonary hypertension, right-left ventricular interaction may lead to severe impairment of left ventricular function. In such cases, many experts favor combined heart-lung transplantation by fear that the left ventricle may not recover after transplantation of the lungs alone. We report a case of primary pulmonary hypertension with severely diminished right and left ventricular function. The patient was rendered amenable to isolated pulmonary transplantation with the endothelin-receptor antagonist bosentan. The medication improved right and left ventricular function to the point that heart transplantation no longer appeared necessary. After double-lung transplantation the patient's cardiac function made a full recovery. This approach might be particularly welcome considering both the current donor organ shortage and the limited number of surgical teams with expertise in heart-lung transplantation.
Keywords AdultAntihypertensive Agents/therapeutic useCombined Modality TherapyHumansHypertension, Pulmonary/complications/therapyLung TransplantationMaleSeverity of Illness IndexSulfonamides/therapeutic useVentricular Dysfunction, Left/etiologyVentricular Dysfunction, Right/etiology
Identifiers
PMID: 15949741
Full text
Article (Published version) (150 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Pneumologie Clinique (576)
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BRAUCHLIN, Andreas et al. Severe left ventricular dysfunction secondary to primary pulmonary hypertension: bridging therapy with bosentan before lung transplantation. In: Journal of Heart and Lung Transplantation, 2005, vol. 24, n° 6, p. 777-80. https://archive-ouverte.unige.ch/unige:39620

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Deposited on : 2014-08-21

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