en
Scientific article
Case report
English

Severe left ventricular dysfunction secondary to primary pulmonary hypertension: bridging therapy with bosentan before lung transplantation

Published inThe Journal of heart and lung transplantation, vol. 24, no. 6, p. 777-780
Publication date2005
Abstract

When right ventricular failure develops secondary to primary pulmonary hypertension, right-left ventricular interaction may lead to severe impairment of left ventricular function. In such cases, many experts favor combined heart-lung transplantation by fear that the left ventricle may not recover after transplantation of the lungs alone. We report a case of primary pulmonary hypertension with severely diminished right and left ventricular function. The patient was rendered amenable to isolated pulmonary transplantation with the endothelin-receptor antagonist bosentan. The medication improved right and left ventricular function to the point that heart transplantation no longer appeared necessary. After double-lung transplantation the patient's cardiac function made a full recovery. This approach might be particularly welcome considering both the current donor organ shortage and the limited number of surgical teams with expertise in heart-lung transplantation.

Keywords
  • Adult
  • Antihypertensive Agents/therapeutic use
  • Combined Modality Therapy
  • Humans
  • Hypertension, Pulmonary/complications/therapy
  • Lung Transplantation
  • Male
  • Severity of Illness Index
  • Sulfonamides/therapeutic use
  • Ventricular Dysfunction, Left/etiology
  • Ventricular Dysfunction, Right/etiology
Citation (ISO format)
BRAUCHLIN, Andreas et al. Severe left ventricular dysfunction secondary to primary pulmonary hypertension: bridging therapy with bosentan before lung transplantation. In: The Journal of heart and lung transplantation, 2005, vol. 24, n° 6, p. 777–780. doi: 10.1016/j.healun.2004.02.020
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1053-2498
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