Scientific article
Open access

Synergistic control of cellular adhesion by transmembrane 9 proteins

Published inMolecular biology of the cell, vol. 14, no. 7, p. 2890-2899
Publication date2003

The transmembrane 9 (TM9) family of proteins contains numerous members in eukaryotes. Although their function remains essentially unknown in higher eukaryotes, the Dictyostelium discoideum Phg1a TM9 protein was recently reported to be essential for cellular adhesion and phagocytosis. Herein, the function of Phg1a and of a new divergent member of the TM9 family called Phg1b was further investigated in D. discoideum. The phenotypes of PHG1a, PHG1b, and PHG1a/PHG1b double knockout cells revealed that Phg1a and Phg1b proteins play a synergistic but not redundant role in cellular adhesion, phagocytosis, growth, and development. Complementation analysis supports a synergistic regulatory function rather than a receptor role for Phg1a and Phg1b proteins. Together, these results suggest that Phg1 proteins act as regulators of cellular adhesion, possibly by controlling the intracellular transport in the endocytic pathway and the composition of the cell surface.

  • Amino Acid Sequence
  • Animals
  • Cell Adhesion/physiology
  • Cell Membrane/metabolism/physiology
  • Dictyostelium/growth & development/metabolism
  • Membrane Proteins/metabolism/physiology
  • Molecular Sequence Data
  • Phagocytosis/physiology
  • Protozoan Proteins/metabolism/physiology
  • Sequence Homology, Amino Acid
Research group
Citation (ISO format)
BENGHEZAL, Mohammed et al. Synergistic control of cellular adhesion by transmembrane 9 proteins. In: Molecular biology of the cell, 2003, vol. 14, n° 7, p. 2890–2899. doi: 10.1091/mbc.E02-11-0724
Main files (1)
Article (Published version)
ISSN of the journal1059-1524

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