&quot;Pseudo-Beijing&quot;: evidence for convergent evolution in the direct repeat region of Mycobacterium tuberculosis

Fenner, Lukas; Malla, Bijaya; Bescher Ninet, Béatrice Alice; Dubuis, Olivier; Stucki, David; Borrell, Sonia; Huna, Thembela; Bodmer, Thomas; Egger, Matthias; Gagneux, Sebastien

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Title		"Pseudo-Beijing": evidence for convergent evolution in the direct repeat region of Mycobacterium tuberculosis
Authors		Fenner, Lukas Malla, Bijaya Bescher Ninet, Béatrice Alice Dubuis, Olivier Stucki, David Borrell, Sonia Huna, Thembela Bodmer, Thomas Egger, Matthias Gagneux, Sebastien show all authors [1 - 10]
Published in		PLOS ONE. 2011, vol. 6, no. 9, p. e24737
Abstract		Mycobacterium tuberculosis has a global population structure consisting of six main phylogenetic lineages associated with specific geographic regions and human populations. One particular M. tuberculosis genotype known as "Beijing" has repeatedly been associated with drug resistance and has been emerging in some parts of the world. "Beijing" strains are traditionally defined based on a characteristic spoligotyping pattern. We used three alternative genotyping techniques to revisit the phylogenetic classification of M. tuberculosis complex (MTBC) strains exhibiting the typical "Beijing" spoligotyping pattern.
Keywords		Biological Evolution — Genotype — Mycobacterium tuberculosis/classification/genetics — Phylogeny — Repetitive Sequences, Nucleic Acid/genetics
Identifiers		DOI: 10.1371/journal.pone.0024737 PMID: 21935448
Full text		Article (Published version) (245 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Citation (ISO format)		FENNER, Lukas et al. "Pseudo-Beijing": evidence for convergent evolution in the direct repeat region of Mycobacterium tuberculosis. In: PLOS ONE, 2011, vol. 6, n° 9, p. e24737. https://archive-ouverte.unige.ch/unige:39491