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"Pseudo-Beijing": evidence for convergent evolution in the direct repeat region of Mycobacterium tuberculosis

Fenner, Lukas
Malla, Bijaya
Dubuis, Olivier
Stucki, David
Borrell, Sonia
Huna, Thembela
Bodmer, Thomas
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Published in PloS one. 2011, vol. 6, no. 9, e24737
Abstract Mycobacterium tuberculosis has a global population structure consisting of six main phylogenetic lineages associated with specific geographic regions and human populations. One particular M. tuberculosis genotype known as "Beijing" has repeatedly been associated with drug resistance and has been emerging in some parts of the world. "Beijing" strains are traditionally defined based on a characteristic spoligotyping pattern. We used three alternative genotyping techniques to revisit the phylogenetic classification of M. tuberculosis complex (MTBC) strains exhibiting the typical "Beijing" spoligotyping pattern.
Keywords Biological EvolutionGenotypeMycobacterium tuberculosis/classification/geneticsPhylogenyRepetitive Sequences, Nucleic Acid/genetics
PMID: 21935448
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FENNER, Lukas et al. "Pseudo-Beijing": evidence for convergent evolution in the direct repeat region of Mycobacterium tuberculosis. In: PloS one, 2011, vol. 6, n° 9, p. e24737. doi: 10.1371/journal.pone.0024737 https://archive-ouverte.unige.ch/unige:39491

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Deposited on : 2014-08-18

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