The present and future disease burden of hepatitis C virus (HCV) infection with today&#039;s treatment paradigm

Razavi, H; Waked, I; Sarrazin, C; Myers, R P; Idilman, R; Calinas, F; Vogel, W; Mendes Correa, M C; Hézode, C; Lázaro, P; Akarca, U; Aleman, S; Balık, I; Berg, T; Bihl, Florian; Bilodeau, M; Blasco, A J; Brandão Mello, C E; Bruggmann, P; Buti, M; Calleja, J L; Cheinquer, H; Christensen, P B; Clausen, M; Coelho, H S M; Cramp, M E; Dore, G J; Doss, W; Duberg, A S; El-Sayed, M H; Ergör, G; Esmat, G; Falconer, K; Félix, J; Ferraz, M L G; Ferreira, P R; Frankova, S; García-Samaniego, J; Gerstoft, J; Giria, J A; Gonçales, F L (Jr); Gower, E; Gschwantler, M; Guimarães Pessôa, M; Hindman, S J; Hofer, H; Husa, P; Kåberg, M; Kaita, K D E; Kautz, A; Kaymakoglu, S; Krajden, M; Krarup, H; Laleman, W; Lavanchy, D; Marinho, R T; Marotta, P; Mauss, S; Moreno, C; Murphy, K; Negro, Francesco; Nemecek, V; Örmeci, N; Øvrehus, A L H; Parkes, J; Pasini, K; Peltekian, K M; Ramji, A; Reis, N; Roberts, S K; Rosenberg, W M; Roudot-Thoraval, F; Ryder, S D; Sarmento-Castro, R; Semela, David; Sherman, M; Shiha, G E; Sievert, W; Sperl, J; Stärkel, P; Stauber, R E; Thompson, A J; Urbanek, P; Van Damme, P; van Thiel, I; Van Vlierberghe, H; Vandijck, D; Wedemeyer, H; Weis, N; Wiegand, J; Yosry, A; Zekry, A; Cornberg, M; Müllhaupt, B; Estes, C

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Title		The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm
Authors		Razavi, H Waked, I Sarrazin, C Myers, R P Idilman, R Calinas, F Vogel, W Mendes Correa, M C Hézode, C Lázaro, P Akarca, U Aleman, S Balık, I Berg, T Bihl, Florian Bilodeau, M Blasco, A J Brandão Mello, C E Bruggmann, P Buti, M Calleja, J L Cheinquer, H Christensen, P B Clausen, M Coelho, H S M Cramp, M E Dore, G J Doss, W Duberg, A S El-Sayed, M H Ergör, G Esmat, G Falconer, K Félix, J Ferraz, M L G Ferreira, P R Frankova, S García-Samaniego, J Gerstoft, J Giria, J A Gonçales, F L (Jr) Gower, E Gschwantler, M Guimarães Pessôa, M Hindman, S J Hofer, H Husa, P Kåberg, M Kaita, K D E Kautz, A Kaymakoglu, S Krajden, M Krarup, H Laleman, W Lavanchy, D Marinho, R T Marotta, P Mauss, S Moreno, C Murphy, K Negro, Francesco Nemecek, V Örmeci, N Øvrehus, A L H Parkes, J Pasini, K Peltekian, K M Ramji, A Reis, N Roberts, S K Rosenberg, W M Roudot-Thoraval, F Ryder, S D Sarmento-Castro, R Semela, David Sherman, M Shiha, G E Sievert, W Sperl, J Stärkel, P Stauber, R E Thompson, A J Urbanek, P Van Damme, P van Thiel, I Van Vlierberghe, H Vandijck, D Wedemeyer, H Weis, N Wiegand, J Yosry, A Zekry, A Cornberg, M Müllhaupt, B Estes, C show all authors [1 - 95]
Published in		Journal of Viral Hepatitis. 2014, vol. 21 Suppl 1, p. 34-59
Abstract		The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.
Identifiers		DOI: 10.1111/jvh.12248 PMID: 24713005
Full text		Article (Author postprint) (1.6 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Etudes et traitement de l'hépatite C et B (554)
Citation (ISO format)		RAZAVI, H et al. The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm. In: Journal of Viral Hepatitis, 2014, vol. 21 Suppl 1, p. 34-59. https://archive-ouverte.unige.ch/unige:39265