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Scientific article
English

Strategies to manage hepatitis C virus (HCV) disease burden

ContributorsWedemeyer, H
Published inJournal of viral hepatitis, vol. 21 Suppl 1, p. 60-89
Publication date2014
Abstract

The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical.

Citation (ISO format)
WEDEMEYER, H. Strategies to manage hepatitis C virus (HCV) disease burden. In: Journal of viral hepatitis, 2014, vol. 21 Suppl 1, p. 60–89. doi: 10.1111/jvh.12249
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ISSN of the journal1352-0504
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Creation08/06/2014 2:18:00 PM
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