Preoperative concomitant hyperfractionated radiotherapy and gemcitabine for locally advanced rectal cancers: a phase I-II trial

Allal, Abdelkarim Said; Bieri, Sabine; Gervaz, Pascal; Soravia, Claudio; Bernier, Jacques; Gertsch, Philippe; Morel, Philippe; Roth, Arnaud

doi:10.1097/00130404-200503000-00008

Scientific article

English

Preoperative concomitant hyperfractionated radiotherapy and gemcitabine for locally advanced rectal cancers: a phase I-II trial

ContributorsAllal, Abdelkarim Said; Bieri, Sabine; Gervaz, Pascal; Soravia, Claudio; Bernier, Jacques; Gertsch, Philippe; Morel, Philippe; Roth, Arnaud

Published inThe cancer journal, vol. 11, no. 2, p. 133-139

Publication date2005

Abstract

The purpose of this study was to determine the maximum tolerated dose of gemcitabine when it was administered concomitantly with hyperfractionated radiotherapy before surgery in patients with locally advanced rectal cancers and to investigate the midterm efficacy of such a regimen.

Keywords

Adult
Aged
Deoxycytidine/administration & dosage/adverse effects/analogs & derivatives/therapeutic use
Dose Fractionation
Female
Humans
Male
Middle Aged
Neoplasm Staging
Preoperative Care
Radiation-Sensitizing Agents/administration & dosage/adverse effects/therapeutic use
Radiotherapy, Adjuvant
Radiotherapy, Conformal
Rectal Neoplasms/drug therapy/pathology/radiotherapy
Survival Analysis
Time Factors
Treatment Outcome

Affiliation entities

Research groups

Citation (ISO format)

ALLAL, Abdelkarim Said et al. Preoperative concomitant hyperfractionated radiotherapy and gemcitabine for locally advanced rectal cancers: a phase I-II trial. In: The cancer journal, 2005, vol. 11, n° 2, p. 133–139. doi: 10.1097/00130404-200503000-00008

Article (Published version)

Identifiers

PID : unige:39101
DOI : 10.1097/00130404-200503000-00008
PMID : 15969988

Commercial URLhttp://journals.lww.com/journalppo/Abstract/2005/03000/Preoperative_Concomitant_Hyperfractionated.8.aspx

Journal ISSN1528-9117

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Preoperative concomitant hyperfractionated radiotherapy and gemcitabine for locally advanced rectal cancers: a phase I-II trial

The purpose of this study was to determine the maximum tolerated dose of gemcitabine when it was administered concomitantly with hyperfractionated radiotherapy before surgery in patients with locally advanced rectal cancers and to investigate the midterm efficacy of such a regimen.

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