Preoperative concomitant hyperfractionated radiotherapy and gemcitabine for locally advanced rectal cancers: a phase I-II trial

Allal, Abdelkarim Said; Bieri, Sabine; Gervaz, Pascal; Soravia, Claudio; Bernier, Jacques; Gertsch, Philippe; Morel, Philippe; Roth, Arnaud

doi:10.1097/00130404-200503000-00008

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Title		Preoperative concomitant hyperfractionated radiotherapy and gemcitabine for locally advanced rectal cancers: a phase I-II trial
Authors		Allal, Abdelkarim Said Bieri, Sabine Gervaz, Pascal Soravia, Claudio Bernier, Jacques Gertsch, Philippe Morel, Philippe Roth, Arnaud
Published in		Cancer Journal. 2005, vol. 11, no. 2, p. 133-9
Abstract		The purpose of this study was to determine the maximum tolerated dose of gemcitabine when it was administered concomitantly with hyperfractionated radiotherapy before surgery in patients with locally advanced rectal cancers and to investigate the midterm efficacy of such a regimen.
Keywords		Adult — Aged — Deoxycytidine/administration & dosage/adverse effects/analogs & derivatives/therapeutic use — Dose Fractionation — Female — Humans — Male — Middle Aged — Neoplasm Staging — Preoperative Care — Radiation-Sensitizing Agents/administration & dosage/adverse effects/therapeutic use — Radiotherapy, Adjuvant — Radiotherapy, Conformal — Rectal Neoplasms/drug therapy/pathology/radiotherapy — Survival Analysis — Time Factors — Treatment Outcome
Identifiers		DOI: 10.1097/00130404-200503000-00008 PMID: 15969988
Full text		Article (Published version) (75 Kb) - Limited access to UNIGE Other version: http://journals.lww.com/journalppo/Abstract/2005/03000/Preoperative_Concomitant_Hyperfractionated.8.aspx
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Chirurgie viscérale (104) Chirurgie viscérale (HUG) Groupe Roth Arnaud (oncologie) (285)
Citation (ISO format)		ALLAL, Abdelkarim Said et al. Preoperative concomitant hyperfractionated radiotherapy and gemcitabine for locally advanced rectal cancers: a phase I-II trial. In: Cancer Journal, 2005, vol. 11, n° 2, p. 133-9. doi: 10.1097/00130404-200503000-00008 https://archive-ouverte.unige.ch/unige:39101

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Deposited on : 2014-08-04

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Preoperative concomitant hyperfractionated radiotherapy and gemcitabine for locally advanced rectal cancers: a phase I-II trial