Scientific article
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English

Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus

Published inInternational journal of colorectal disease, vol. 20, no. 2, p. 161-164
Collection
  • Open Access - Licence nationale Springer
Publication date2005
Abstract

Histologically, tumors of the anal region are either keratinizing (K) or non-keratinizing (NK) squamous cell carcinomas (SCCA). We hypothesized that these two variants might represent, not only morphologically, but also biologically, dissimilar malignancies. The present study was undertaken to compare the expression of apoptosis-regulating proteins Bcl-2 and p53 in K versus NK SCCA.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Anus Neoplasms/metabolism/pathology
  • Apoptosis
  • Biopsy
  • Carcinoma, Squamous Cell/metabolism/pathology
  • Female
  • Humans
  • Immunohistochemistry
  • Keratinocytes/metabolism/pathology
  • Male
  • Middle Aged
  • Prognosis
  • Proto-Oncogene Proteins c-bcl-2/biosynthesis
  • Retrospective Studies
  • Sex Factors
  • Tumor Markers, Biological/biosynthesis
  • Tumor Suppressor Protein p53/biosynthesis
Citation (ISO format)
ALLAL, Abdelkarim Said, BRUNDLER, Marie-Anne, GERVAZ, Pascal. Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. In: International journal of colorectal disease, 2005, vol. 20, n° 2, p. 161–164. doi: 10.1007/s00384-004-0651-z
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN0179-1958
715views
335downloads

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