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Title

Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus

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Published in International Journal of Colorectal Disease, Clinical and Molecular Gastroenterology and Surgery. 2005, vol. 20, no. 2, p. 161-4
Collection Open Access - Licence nationale Springer
Abstract Histologically, tumors of the anal region are either keratinizing (K) or non-keratinizing (NK) squamous cell carcinomas (SCCA). We hypothesized that these two variants might represent, not only morphologically, but also biologically, dissimilar malignancies. The present study was undertaken to compare the expression of apoptosis-regulating proteins Bcl-2 and p53 in K versus NK SCCA.
Keywords AdultAgedAged, 80 and overAnus Neoplasms/metabolism/pathologyApoptosisBiopsyCarcinoma, Squamous Cell/metabolism/pathologyFemaleHumansImmunohistochemistryKeratinocytes/metabolism/pathologyMaleMiddle AgedPrognosisProto-Oncogene Proteins c-bcl-2/biosynthesisRetrospective StudiesSex FactorsTumor Markers, Biological/biosynthesisTumor Suppressor Protein p53/biosynthesis
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PMID: 15688099
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Article (Published version) (137 Kb) - public document Free access
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Research group Chirurgie viscérale (104)
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ALLAL, Abdelkarim Said, BRUNDLER, Marie-Anne, GERVAZ, Pascal. Differential expression of anti-apoptotic protein Bcl-2 in keratinizing versus non-keratinizing squamous cell carcinoma of the anus. In: International Journal of Colorectal Disease, Clinical and Molecular Gastroenterology and Surgery, 2005, vol. 20, n° 2, p. 161-4. https://archive-ouverte.unige.ch/unige:39100

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Deposited on : 2014-08-04

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