Pre-retrieval reperfusion decreases cancer recurrence after rat ischemic liver graft transplantation

Oldani, Graziano; Crowe, Lindsey A; Orci, Lorenzo; Slits, Florence; Rubbia-Brandt, Laura; De Vito, Claudio; Morel, Philippe; Mentha, Gilles; Berney, Thierry; Vallée, Jean-Paul; Lacotte, Stéphanie; Toso, Christian

doi:10.1016/j.jhep.2014.03.036

Scientific article

English

Pre-retrieval reperfusion decreases cancer recurrence after rat ischemic liver graft transplantation

ContributorsOldani, Graziano; Crowe, Lindsey A; Orci, Lorenzo; Slits, Florence; Rubbia-Brandt, Laura; De Vito, Claudio; Morel, Philippe; Mentha, Gilles; Berney, Thierry; Vallée, Jean-Paul

; Lacotte, Stéphanie

; Toso, Christian

Published inJournal of hepatology, vol. 61, no. 2, p. 278-285

Publication date2014

Abstract

Liver transplantation from marginal donors is associated with ischemia/reperfusion (I/R) lesions, which may increase the risk of post-transplant hepatocellular carcinoma (HCC) recurrence. Graft reperfusion prior to retrieval (as for extracorporeal membrane oxygenation - ECMO) can prevent I/R lesions. The impact of I/R on the risk of cancer recurrence was assessed on a syngeneic Fischer-rat liver transplantation model.

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Citation (ISO format)

OLDANI, Graziano et al. Pre-retrieval reperfusion decreases cancer recurrence after rat ischemic liver graft transplantation. In: Journal of hepatology, 2014, vol. 61, n° 2, p. 278–285. doi: 10.1016/j.jhep.2014.03.036

Article (Published version)

Identifiers

PID : unige:39093
DOI : 10.1016/j.jhep.2014.03.036
PMID : 24713189

Journal ISSN0168-8278

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Pre-retrieval reperfusion decreases cancer recurrence after rat ischemic liver graft transplantation

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