Chylopericardium after intrathoracic surgical procedures rarely occurs. Optimal guidelines for the management of chylopericardium are lacking. In this case report, we describe our experience in treating chylopericadium with somatostatin in a 47-year-old man who underwent replacement of the ascending aorta and aortic valvuloplasty after aortic rupture. Postoperatively, a late tamponade was drained, and microbiologic analyses confirmed chyle. Conservative treatment including total parental nutrition failed, so we initiated somatostatin treatment as a continuous perfusion, with good results.