The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology?

Conne, Béatrice; Stutz, André; Vassalli, Jean-Dominique

doi:10.1038/76211

Scientific article

English

The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology?

ContributorsConne, Béatrice; Stutz, André; Vassalli, Jean-Dominique

Published inNature medicine, vol. 6, no. 6, p. 637-641

Publication date2000

Abstract

The role of the 3' untranslated region in posttranscriptional regulation of mRNA expression is being elucidated. Here we describe diseases arising from anomalies in this region, that affect the expression of one or more genes.

Keywords

3' Untranslated Regions/physiology
Animals
Humans
Myotonic Dystrophy/genetics
Protein Biosynthesis
RNA Processing, Post-Transcriptional
RNA Stability

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

Citation (ISO format)

CONNE, Béatrice, STUTZ, André, VASSALLI, Jean-Dominique. The 3′ untranslated region of messenger RNA: A molecular “hotspot” for pathology? In: Nature medicine, 2000, vol. 6, n° 6, p. 637–641. doi: 10.1038/76211

Article (Accepted version)

Identifiers

PID : unige:3896
DOI : 10.1038/76211
PMID : 10835679

Additional URL for this publicationhttp://www.nature.com/nm/journal/v6/n6/full/nm0600_637.html

Journal ISSN1078-8956

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The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology?

The role of the 3' untranslated region in posttranscriptional regulation of mRNA expression is being elucidated. Here we describe diseases arising from anomalies in this region, that affect the expression of one or more genes.

Technical informations