en
Scientific article
English

Neural transition from short- to long-term memory and the medial temporal lobe: a human evoked-potential study

Published inHippocampus, vol. 19, no. 4, p. 371-378
Publication date2009
Abstract

Recent studies indicated that the human medial temporal lobe (MTL) may not only be important for long-term memory consolidation but also for certain forms of short-term memory. In this study, we explored the interplay between short- and long-term memory using high-density event-related potentials. We found that pictures immediately repeated after an unfilled interval were better recognized than pictures repeated after intervening items. After 30 min, however, the immediately repeated pictures were significantly less well recognized than pictures repeated after intervening items. This processing advantage at immediate repetition but disadvantage for long-term storage had an electrophysiological correlate: spatiotemporal analysis showed that immediate repetition induced a strikingly different electrocortical response after 200-300 ms, with inversed polarity, than new stimuli and delayed repetitions. Inverse solutions indicated that this difference reflected transient activity in the MTL. The findings demonstrate behavioral and electrophysiological dissociation between recognition during active maintenance and recognition after intervening items. Processing of novel information seems to immediately initiate a consolidation process, which remains vulnerable during active maintenance and increases its effectiveness during off-line processing.

Keywords
  • Adult
  • Analysis of Variance
  • Brain Mapping
  • Electroencephalography
  • Evoked Potentials
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory/physiology
  • Pattern Recognition, Visual/physiology
  • Photic Stimulation
  • Temporal Lobe/physiology
  • Time
Citation (ISO format)
JAMES, Clara et al. Neural transition from short- to long-term memory and the medial temporal lobe: a human evoked-potential study. In: Hippocampus, 2009, vol. 19, n° 4, p. 371–378. doi: 10.1002/hipo.20526
Main files (1)
Article (Accepted version)
accessLevelRestricted
Identifiers
ISSN of the journal1098-1063
593views
0downloads

Technical informations

Creation10/21/2009 5:11:00 PM
First validation10/21/2009 5:11:00 PM
Update time03/14/2023 3:16:50 PM
Status update03/14/2023 3:16:49 PM
Last indexation05/02/2024 11:21:55 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack