UNIGE document Scientific Article
previous document  unige:3845  next document
add to browser collection
Title

Prenatal nicotine exposure and the programming of metabolic and cardiovascular disorders

Authors
Vauthay, Delphine M.
Published in Molecular and Cellular Endocrinology. 2009, vol. 304, no. 1-2, p. 69-77
Abstract Presently, a growing interest is focused on the origins of the "Metabolic Syndrome", a cluster of several metabolic disorders linking obesity, dyslipidemia, hypertension and type 2 diabetes mellitus. Clearly, genetic predisposition and deleterious lifestyle, including low physical activity and hypercaloric alimentation, have an influence on the occurrence of the Metabolic Syndrome. However, recent data suggest that the Metabolic Syndrome could also be "programmed" during intrauterine life by diverse insults to the growing foetus. Nicotine is the main stimulant and dependence-forming alkaloid found in tobacco, and despite medical advice, statistics show that 20-30% of female smokers continue the habit during gestation, representing around 10% of all pregnancies. In consequence, nicotine is one of the most universally dangerous chemicals to which developing foetuses are exposed. The present review focuses on recent epidemiological surveys and experimental animal studies that provide evidences indicating that pre- and postnatal nicotine exposure might be a contributing factor for the occurrence of metabolic disorders later in life.
Keywords AnimalsBlood Glucose/metabolismCardiovascular Diseases/etiology/metabolismFemaleFetus/drug effectsHomeostasisHumansMetabolic Diseases/metabolismNicotine/adverse effects/metabolism/pharmacologyObesity/etiology/metabolismPancreas/drug effects/physiologyPregnancyPrenatal Exposure Delayed EffectsSmoking/adverse effects
Identifiers
PMID: 19433250
Full text
Article (Author postprint) (302 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Etude des altérations du gène ATM dans divers cancers de l'enfant (178)
L'imagerie cérébrale (184)
Citation
(ISO format)
SOMM, Emmanuel Paul et al. Prenatal nicotine exposure and the programming of metabolic and cardiovascular disorders. In: Molecular and cellular endocrinology, 2009, vol. 304, n° 1-2, p. 69-77. https://archive-ouverte.unige.ch/unige:3845

180 hits

1 download

Update

Deposited on : 2009-10-20

Export document
Format :
Citation style :