UNIGE document Scientific Article
previous document  unige:38256  next document
add to browser collection
Title

Drug-evoked synaptic plasticity: beyond metaplasticity

Authors
Published in Current Opinion in Neurobiology. 2013, vol. 23, no. 4, p. 553-8
Abstract Addictive drugs such as cocaine induce synaptic plasticity in the ventral tegmental area and its projection areas, which may represent the cellular correlate of an addiction trace. Cocaine induces changes in excitatory transmission primarily in the VTA, which persists for days after a single exposure. These initial alterations in synaptic transmission represent a metaplasticity that is permissive for late stages of remodeling throughout the mesocorticolimbic circuitry, specifically in the NAc. Specific synaptic and cellular changes in the NAc persist following prolonged exposure to cocaine, and this remodeling may contribute to altered behavior. By manipulating synaptic activity in the NAc, it may be possible to reverse pathological synaptic transmission and its associated abnormal behavior following exposure to addictive drugs.
Keywords AnimalsHumansLimbic System/cytology/drug effectsNeuronal Plasticity/drug effectsStreet Drugs/pharmacologySynaptic Transmission/drug effects
Identifiers
PMID: 23571119
Full text
Article (Published version) (691 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
Citation
(ISO format)
CREED, Meaghan, LUSCHER, Christian. Drug-evoked synaptic plasticity: beyond metaplasticity. In: Current Opinion in Neurobiology, 2013, vol. 23, n° 4, p. 553-8. https://archive-ouverte.unige.ch/unige:38256

220 hits

0 download

Update

Deposited on : 2014-06-26

Export document
Format :
Citation style :