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Viral DNA polymerase scanning and the gymnastics of Sendai virus RNA synthesis

Published in Virology. 2004, vol. 318, no. 2, p. 463-73
Abstract mRNA synthesis from nonsegmented negative-strand RNA virus (NNV) genomes is unique in tht the genome RNA is embedded in an N protein assembly (the nucleocapsid) and the viral RNA polymerase does not dissociate from the template after release of each mRNA, but rather scans the genome RNA for the next gene-start site. A revised model for NNV RNA synthesis is presented, in which RNA polymerase scanning plays a prominent role. Polymerase scanning of the template is known to occur as the viral transcriptase negotiates gene junctions without falling off the template.
Keywords DNA-Directed RNA Polymerases/chemistry/metabolismNucleocapsid Proteins/metabolismRNA, Messenger/metabolismRNA, Viral/biosynthesisSendai virus/genetics/metabolismTranscription, GeneticVesicular stomatitis Indiana virus/genetics
PMID: 15015496
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Research group Virologie moléculaire (275)
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KOLAKOFSKY, Daniel et al. Viral DNA polymerase scanning and the gymnastics of Sendai virus RNA synthesis. In: Virology, 2004, vol. 318, n° 2, p. 463-73. doi: 10.1016/j.virol.2003.10.031 https://archive-ouverte.unige.ch/unige:38142

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Deposited on : 2014-06-25

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