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Longer and shorter forms of Sendai virus C proteins play different roles in modulating the cellular antiviral response

Itoh, M
Published in Journal of Virology. 2001, vol. 75, no. 15, p. 6800-7
Abstract The Sendai virus (SeV) C gene codes for a nested set of four C proteins that carry out several functions, including the modulation of viral RNA synthesis and countering of the cellular antiviral response. Using mutant C genes (and in particular a C gene with a deletion of six amino acids present only in the larger pair of C proteins) and recombinant SeV carrying these mutant C genes, we find that the nested set of C proteins carry out a nested set of functions. All of the C proteins interdict interferon (IFN) signaling to IFN-stimulated genes (ISGs) and prevent pY701-Stat1 formation. However, only the larger C proteins can induce STAT1 instability, prevent IFN from inducing an antiviral state, or prevent programmed cell death. Remarkably, interdiction of IFN signaling to ISGs and the absence of pY701-Stat1 formation did not prevent IFN-alpha from inducing an anti-Vesicular stomatitis virus (VSV) state. It is possible that IFN-alpha signaling to induce an anti-VSV state can occur independently of the well-established Jak/Stat/ISGF3 pathway and that it is this parallel pathway that is targeted by the longer C proteins.
Keywords Amino Acid SequenceAnimalsAntiviral Agents/metabolism/pharmacologyCell LineCricetinaeCytopathogenic Effect, ViralDNA-Binding Proteins/metabolismGenes, ViralHeLa CellsHumansInterferon-Stimulated Gene Factor 3Interferon-Stimulated Gene Factor 3, gamma SubunitInterferon-alpha/metabolism/pharmacologyJanus Kinase 1Macaca mulattaMiceMice, Inbred BALB CMolecular Sequence DataProtein Isoforms/genetics/metabolism/physiologyProtein-Tyrosine Kinases/metabolismRNA, Viral/biosynthesisRespirovirus/metabolism/physiologySTAT1 Transcription FactorSignal TransductionTrans-Activators/metabolismTranscription Factors/metabolismViral Proteins/genetics/metabolism/physiology
PMID: 11435558
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Article (Published version) (2.1 MB) - public document Free access
Research group Virologie moléculaire (275)
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GARCIN, Dominique et al. Longer and shorter forms of Sendai virus C proteins play different roles in modulating the cellular antiviral response. In: Journal of Virology, 2001, vol. 75, n° 15, p. 6800-7. https://archive-ouverte.unige.ch/unige:38129

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Deposited on : 2014-06-25

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