UNIGE document Scientific Article
previous document  unige:38128  next document
add to browser collection
Title

Sendai virus C proteins must interact directly with cellular components to interfere with interferon action

Authors
Published in Journal of Virology. 2000, vol. 74, no. 19, p. 8823-30
Abstract Sendai virus (SeV) infection of interferon (IFN)-competent cells is one of the most efficient ways of inducing IFN production. Virus replication is nevertheless largely unaffected, since SeV infection also interfers with IFN action, a prerequisite for the establishment of an antiviral state. This property has been mapped by reverse genetics to the viral C gene, which is also known to act as a promoter-specific inhibitor of viral RNA synthesis. Using luciferase reporter plasmids containing IFN-responsive promoters, we have found that all four C proteins effectively interdict IFN signaling when expressed independently of SeV infection. The C proteins must therefore interact directly with cellular components to carry this out. The C gene in the context of an SeV infection was also found to induce STAT1 instability in some cells, whereas in other cells it apparently acts to prevent the synthesis of STAT1 in response to the virus infection or IFN treatment. The SeV C proteins appear to act in at least two ways to counteract the IFN induced by SeV infection.
Keywords AnimalsInterferons/metabolism/pharmacologyMiceRespirovirus/physiologyRespirovirus Infections/metabolism/virologySignal TransductionViral Proteins/physiologyVirus Replication
Identifiers
PMID: 10982324
Full text
Article (Published version) (865 Kb) - public document Free access
Structures
Research group Virologie moléculaire (275)
Citation
(ISO format)
GARCIN, Dominique, CURRAN, Joseph, KOLAKOFSKY, Daniel. Sendai virus C proteins must interact directly with cellular components to interfere with interferon action. In: Journal of Virology, 2000, vol. 74, n° 19, p. 8823-30. https://archive-ouverte.unige.ch/unige:38128

238 hits

124 downloads

Update

Deposited on : 2014-06-25

Export document
Format :
Citation style :