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Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators

Theraulaz, Laurence
Nesper, Jutta
Abel, Sören
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Published in Nature communications. 2014, vol. 5, 4081
Abstract Zinc-finger domain transcriptional regulators regulate a myriad of functions in eukaryotes. Interestingly, ancestral versions (MucR) from Alpha-proteobacteria control bacterial virulence/symbiosis. Whether virulence regulators can also control cell cycle transcription is unknown. Here we report that MucR proteins implement a hitherto elusive primordial S→G1 transcriptional switch. After charting G1-specific promoters in the cell cycle model Caulobacter crescentus by comparative ChIP-seq, we use one such promoter as genetic proxy to unearth two MucR paralogs, MucR1/2, as constituents of a quadripartite and homeostatic regulatory module directing the S→G1 transcriptional switch. Surprisingly, MucR orthologues that regulate virulence and symbiosis gene transcription in Brucella, Agrobacterium or Sinorhizobium support this S→G1 switch in Caulobacter. Pan-genomic ChIP-seq analyses in Sinorhizobium and Caulobacter show that this module indeed targets orthologous genes. We propose that MucR proteins and possibly other virulence regulators primarily control bacterial cell cycle (G1-phase) transcription, rendering expression of target (virulence) genes periodic and in tune with the cell cycle.
PMID: 24939058
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Article (Published version) (4.6 MB) - public document Free access
Research group Régulation du cycle cellulaire dans C.crescentus, une bactérie asymétrique (895)
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FUMEAUX, Coralie et al. Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators. In: Nature Communications, 2014, vol. 5, p. 4081. doi: 10.1038/ncomms5081 https://archive-ouverte.unige.ch/unige:38108

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Deposited on : 2014-06-25

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