We report the first measurements of inclusive W and Z cross sections times leptonic branching ratios for pp¯ collisions at s√=1.96  TeV, based on their decays to electrons and muons. The data correspond to an integrated luminosity of 72  pb−1 recorded with the CDF detector at the Fermilab Tevatron. We test e-μ universality in W decays, and we measure the ratio of leptonic W and Z rates from which the leptonic branching fraction B(W→ℓν) can be extracted as well as an indirect value for the total width of the W and the Cabibbo-Kobayashi-Maskawa matrix element, |Vcs|.